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Gene Review

LLT  -  miscRNA

Suid herpesvirus 1

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High impact information on LLT

  • LLT beta delta 2 replicated efficiently at the site of inoculation and in peripheral nervous tissues, but replication was restricted in the central nervous system [1].
  • In this report, we investigated the effect of the deletion on PRV replication and virulence after intracranial inoculation of swine, in comparison to replication and virulence after intranasal inoculation, in order to more precisely locate the defect in LLT beta delta 2 [2].
  • LLT beta delta 2 was able to replicate in the CNS after intracranial inoculation into the cerebral cortex of 2-day-old piglets and to spread from CNS to peripheral tissues [2].

Biological context of LLT

  • Compared to the parental strain, Indiana-Funkhauser, and a virus rescued for the deleted sequences (LLT beta res), LLT beta delta 2 replicated efficiently at the site of inoculation, yet exhibited significantly reduced virulence when inoculated intranasally in pigs [2].


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