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Gene Review:

US2 - possibly envelope-associated; interacts...

Suid herpesvirus 1

Clase, A.C. et al., Rijsewijk, F.A. et al., van Zijl, M. et al.

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Disease relevance of US2

Part of the amino acid sequence of 28K is homologous to the predicted US2 protein of HSV-1 [1].
Curiously, the Us2 protein isolated from purified virions does not appear to be prenylated [2].
The pseudorabies virus Us2 protein, a virion tegument component, is prenylated in infected cells [2].

High impact information on US2

We demonstrate here that the pseudorabies virus (PRV) Us2 protein is synthesized early after infection and localizes to cytoplasmic vesicles and to the plasma membrane, despite the lack of a recognizable signal sequence or membrane-spanning domain [2].
Spontaneous BHV1 recombinants in which the gI/gE/US9 region is replaced by a duplication/inversion of the US1.5/US2 region [3].

References

Identification of two genes in the unique short region of pseudorabies virus; comparison with herpes simplex virus and varicella-zoster virus. van Zijl, M., van der Gulden, H., de Wind, N., Gielkens, A., Berns, A. J. Gen. Virol. (1990) [Pubmed]
The pseudorabies virus Us2 protein, a virion tegument component, is prenylated in infected cells. Clase, A.C., Lyman, M.G., del Rio, T., Randall, J.A., Calton, C.M., Enquist, L.W., Banfield, B.W. J. Virol. (2003) [Pubmed]
Spontaneous BHV1 recombinants in which the gI/gE/US9 region is replaced by a duplication/inversion of the US1.5/US2 region. Rijsewijk, F.A., Verschuren, S.B., Madić, J., Ruuls, R.C., Renaud, P., van Oirschot, J.T. Arch. Virol. (1999) [Pubmed]

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