The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Herpesvirus 1, Human

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Herpesvirus 1, Human

  • Herpes simplex host/viral interaction database   with KEGG pathway analysis of the viral life cycle  
  • Herpes simplex virus type 1 (HSV-1) binds to cells through interactions of viral glycoproteins gB and gC with heparan sulfate chains on cell surface proteoglycans [1].
  • Most importantly, BILS 179 BS was orally active against HSV infections in murine models of HSV-1 and HSV-2 disease and more effective than acyclovir when the treatment frequency per day was reduced or when initiation of treatment was delayed up to 65 hours after infection [2].
  • A defective herpes simplex virus 1 (HSV-1) vector, pHSVlac, has been developed that contains a transcription unit that places the Escherichia coli lacZ gene under the control of the HSV-1 immediate early 4/5 promoter [3].
  • We observed that, when compared to HSV-1, EBV is a stronger inducer of IL-6 [4].
  • BACKGROUND: Thymidine kinase-deficient herpes simplex virus type 1 [tk(-) HSV-1] replicates well in dividing cells but not in nondividing cells such as neurons, suggesting a potential use in the treatment of brain tumors [5].

Psychiatry related information on Herpesvirus 1, Human


High impact information on Herpesvirus 1, Human

  • Here, we show that heparan sulfate modified by a subset of the multiple D-glucosaminyl 3-O-sulfotransferase isoforms provides sites for the binding of a third viral glycoprotein, gD, and for initiation of HSV-1 entry [1].
  • We conclude that susceptibility of cells to HSV-1 entry depends on (1) presence of heparan sulfate chains to which virus can bind and (2) 3-O-sulfation of specific glucosamine residues in heparan sulfate to generate gD-binding sites or the expression of other previously identified gD-binding receptors [1].
  • Human TK- 143 cells were converted to TK+ phenotype with a plasmid containing the native herpes simplex virus 1 (HSV-1), thymidine kinase, a beta gene, and a chimeric ovalbumin gene consisting of the coding sequences of the ovalbumin gene linked to the promoter-regulatory region of the HSV-1 alpha 4 gene [7].
  • Transfection experiments with HSV 1 in which one uses herpes simplex virus (HSV) thymidine kinase (TK) as a selectable prototrophic marker yield two classes of transformed cells: stable and unstable [8].
  • Herpes simplex virus type 1 (HSV-1) Us11 protein, a true late gene product packaged within the virion, is delivered into cells after infection, exhibits a nucleocytoplasmic localization at early times, and later accumulates in the nucleoli [9].

Chemical compound and disease context of Herpesvirus 1, Human

  • We have discovered a ubiquitin (Ub)-specific cysteine protease encoded within the N-terminal approximately 500 residues of the UL36 gene product, the largest (3164 aa) tegument protein of herpes simplex virus 1 (HSV-1) [10].
  • To elucidate the role of nitric oxide in the pathogenesis of HSV-1 pneumonia, infected mice were treated either with the inhibitor of nitric oxide synthase activity, N(G)-monomethyl-L-arginine (L-NMMA), or, as a control, with PBS or D-NMMA [11].
  • Leukocyte cultures incubated with virus (i.e. HSV-1, Influenza A, and Adeno-1) but not exposed to ragweed antigen E or anti-IgE fail to release histamine [12].
  • A single dose of S-nitroso-L-acetyl penicillamine 3 h after infection inhibited HSV 1 replication in Vero, HEp2, and RAW 264.7 cells in a dose-dependent manner [13].
  • The ability of the mutant Vmw110 polypeptides to activate gene expression (in the presence of Vmw175) from the HSV-1 glycoprotein gD promoter linked to the chloramphenicol acetyl transferase gene was studied [14].

Biological context of Herpesvirus 1, Human

  • Phosphorylation of eIF4E by Mnk-1 enhances HSV-1 translation and replication in quiescent cells [15].
  • Evidence of DNA: protein interactions that mediate HSV-1 immediate early gene activation by VP16 [16].
  • This sequence contains specific promoter elements because replacement of this sequence with either the TATA box of the HSV-1 early thymidine kinase (tk) gene or two random TATA-like elements results in a transcriptionally inactive gC gene [17].
  • We have developed systems to visualize parental and replicated herpes simplex virus type 1 (HSV-1) amplicon genomes in association with PML nuclear bodies (ND10) in live cells [18].
  • Bacteria cured of plasmid pAGO (or transformed by plasmid pBR322) did not show enhanced incorporation of [3H]dThd into DNA or HSV-1 TK activity [19].

Anatomical context of Herpesvirus 1, Human

  • Guinea pigs were vaccinated with truncated herpes simplex virus type-1 (HSV-1) glycoprotein D produced in the genetically engineered mammalian cell line gD10 [20].
  • HveC was expressed in human cells of epithelial and neuronal origin; it is the prime candidate for the coreceptor that allows both HSV-1 and HSV-2 to infect epithelial cells on mucosal surfaces and spread to cells of the nervous system [21].
  • Herpes simplex virus (HSV) 1 and 2 infect activated T lymphocytes by attachment of the HSV envelope glycoprotein D (gD) to the cellular herpesvirus entry mediator (HVEM), an orphan member of the tumor necrosis factor receptor superfamily [22].
  • Augmentation of natural killer (NK) activity by influenza A/PC and HSV-1 viruses appears to be caused by the induction of interferon (IFN) within the NK cell population itself [23].
  • In a mouse model of herpes simplex virus (HSV) 1 corneal infection, tissue destruction results from a CD4+ T cell-mediated chronic inflammation, in which interleukin 2 and interferon (IFN) gamma are requisite inflammatory mediators and polymorphonuclear leukocytes (PMN) are the predominant infiltrating cells [24].

Gene context of Herpesvirus 1, Human

  • Thus, these studies suggest the TLR2-mediated cytokine response to HSV-1 is detrimental to the host [25].
  • Because passive transfer of hyperimmune serum protected mice from HSV-1 infection, we hypothesized that CD40 ligand (CD40L), which induces B-cell maturation, would protect mice from HSV-1 infection [26].
  • Finally, analysis of circulating plasmacytoid DCs demonstrates a normal percentage of this subset in CD40-deficient cells, but IFN-alpha secretion in response to herpes simplex virus 1 (HSV-1) infection is severely reduced in patients [27].
  • The role of the UL52 product in the active HSV-1 helicase-primase was examined [28].
  • Herpes simplex virus type 1 (HSV-1) encodes a helicase-primase that consists of the products of the UL5, UL8, and UL52 genes (Crute, J. J., Tsurumi, T., Zhu, L., Weller, S. K., Olivo, P. D., Challberg, M. D., Mocarski, E. S. and Lehman, I. R. (1989) Proc. Natl. Acad. Sci. U. S. A. 86, 2186-2189) [29].

Analytical, diagnostic and therapeutic context of Herpesvirus 1, Human



  1. A novel role for 3-O-sulfated heparan sulfate in herpes simplex virus 1 entry. Shukla, D., Liu, J., Blaiklock, P., Shworak, N.W., Bai, X., Esko, J.D., Cohen, G.H., Eisenberg, R.J., Rosenberg, R.D., Spear, P.G. Cell (1999) [Pubmed]
  2. Herpes simplex virus helicase-primase inhibitors are active in animal models of human disease. Crute, J.J., Grygon, C.A., Hargrave, K.D., Simoneau, B., Faucher, A.M., Bolger, G., Kibler, P., Liuzzi, M., Cordingley, M.G. Nat. Med. (2002) [Pubmed]
  3. A defective HSV-1 vector expresses Escherichia coli beta-galactosidase in cultured peripheral neurons. Geller, A.I., Breakefield, X.O. Science (1988) [Pubmed]
  4. Infection of peripheral blood mononuclear cells by herpes simplex and Epstein-Barr viruses. Differential induction of interleukin 6 and tumor necrosis factor-alpha. Gosselin, J., Flamand, L., D'Addario, M., Hiscott, J., Menezes, J. J. Clin. Invest. (1992) [Pubmed]
  5. Selective destruction of gliomas in immunocompetent rats by thymidine kinase-defective herpes simplex virus type 1. Jia, W.W., McDermott, M., Goldie, J., Cynader, M., Tan, J., Tufaro, F. J. Natl. Cancer Inst. (1994) [Pubmed]
  6. Reactivation of HSV-1 in the brain of patients with familial Alzheimer's disease. Mori, I., Kimura, Y., Naiki, H., Matsubara, R., Takeuchi, T., Yokochi, T., Nishiyama, Y. J. Med. Virol. (2004) [Pubmed]
  7. The alpha promoter regulator-ovalbumin chimeric gene resident in human cells is regulated like the authentic alpha 4 gene after infection with herpes simplex virus 1 mutants in alpha 4 gene. Herz, C., Roizman, B. Cell (1983) [Pubmed]
  8. A herpes simplex virus 1 integration site in the mouse genome defined by somatic cell genetic analysis. Smiley, J.R., Steege, D.A., Juricek, D.K., Summers, W.P., Ruddle, F.H. Cell (1978) [Pubmed]
  9. Post-transcriptional transactivation of human retroviral envelope glycoprotein expression by herpes simplex virus Us11 protein. Diaz, J.J., Dodon, M.D., Schaerer-Uthurralt, N., Simonin, D., Kindbeiter, K., Gazzolo, L., Madjar, J.J. Nature (1996) [Pubmed]
  10. A deubiquitinating enzyme encoded by HSV-1 belongs to a family of cysteine proteases that is conserved across the family Herpesviridae. Kattenhorn, L.M., Korbel, G.A., Kessler, B.M., Spooner, E., Ploegh, H.L. Mol. Cell (2005) [Pubmed]
  11. Suppression of herpes simplex virus type 1 (HSV-1)-induced pneumonia in mice by inhibition of inducible nitric oxide synthase (iNOS, NOS2). Adler, H., Beland, J.L., Del-Pan, N.C., Kobzik, L., Brewer, J.P., Martin, T.R., Rimm, I.J. J. Exp. Med. (1997) [Pubmed]
  12. Enhancement of IgE-mediated histamine release from human basophils by viruses: role of interferon. Ida, S., Hooks, J.J., Siraganian, R.P., Notkins, A.L. J. Exp. Med. (1977) [Pubmed]
  13. Evidence for antiviral effect of nitric oxide. Inhibition of herpes simplex virus type 1 replication. Croen, K.D. J. Clin. Invest. (1993) [Pubmed]
  14. A detailed mutational analysis of Vmw110, a trans-acting transcriptional activator encoded by herpes simplex virus type 1. Everett, R.D. EMBO J. (1987) [Pubmed]
  15. Phosphorylation of eIF4E by Mnk-1 enhances HSV-1 translation and replication in quiescent cells. Walsh, D., Mohr, I. Genes Dev. (2004) [Pubmed]
  16. Evidence of DNA: protein interactions that mediate HSV-1 immediate early gene activation by VP16. Triezenberg, S.J., LaMarco, K.L., McKnight, S.L. Genes Dev. (1988) [Pubmed]
  17. A specific 15-bp TATA box promoter element is required for expression of a herpes simplex virus type 1 late gene. Homa, F.L., Glorioso, J.C., Levine, M. Genes Dev. (1988) [Pubmed]
  18. Visualization of parental HSV-1 genomes and replication compartments in association with ND10 in live infected cells. Sourvinos, G., Everett, R.D. EMBO J. (2002) [Pubmed]
  19. Herpes simplex virus thymidine kinase activity of thymidine kinase-deficient Escherichia coli K-12 mutant transformed by hybrid plasmids. Kit, S., Otsuka, H., Qavi, H., Hazen, M. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  20. Protection from genital herpes simplex virus type 2 infection by vaccination with cloned type 1 glycoprotein D. Berman, P.W., Gregory, T., Crase, D., Lasky, L.A. Science (1985) [Pubmed]
  21. Entry of alphaherpesviruses mediated by poliovirus receptor-related protein 1 and poliovirus receptor. Geraghty, R.J., Krummenacher, C., Cohen, G.H., Eisenberg, R.J., Spear, P.G. Science (1998) [Pubmed]
  22. LIGHT, a new member of the TNF superfamily, and lymphotoxin alpha are ligands for herpesvirus entry mediator. Mauri, D.N., Ebner, R., Montgomery, R.I., Kochel, K.D., Cheung, T.C., Yu, G.L., Ruben, S., Murphy, M., Eisenberg, R.J., Cohen, G.H., Spear, P.G., Ware, C.F. Immunity (1998) [Pubmed]
  23. Positive self regulation of cytotoxicity in human natural killer cells by production of interferon upon exposure to influenza and herpes viruses. Djeu, J.Y., Stocks, N., Zoon, K., Stanton, G.J., Timonen, T., Herberman, R.B. J. Exp. Med. (1982) [Pubmed]
  24. Interferon gamma regulates platelet endothelial cell adhesion molecule 1 expression and neutrophil infiltration into herpes simplex virus-infected mouse corneas. Tang, Q., Hendricks, R.L. J. Exp. Med. (1996) [Pubmed]
  25. Herpes simplex virus 1 interaction with Toll-like receptor 2 contributes to lethal encephalitis. Kurt-Jones, E.A., Chan, M., Zhou, S., Wang, J., Reed, G., Bronson, R., Arnold, M.M., Knipe, D.M., Finberg, R.W. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  26. Recombinant CD40L treatment protects allogeneic murine bone marrow transplant recipients from death caused by herpes simplex virus-1 infection. Beland, J.L., Adler, H., Del-Pan, N.C., Kozlow, W., Sung, J., Fanslow, W., Rimm, I.J. Blood (1998) [Pubmed]
  27. Functional defects of dendritic cells in patients with CD40 deficiency. Fontana, S., Moratto, D., Mangal, S., De Francesco, M., Vermi, W., Ferrari, S., Facchetti, F., Kutukculer, N., Fiorini, C., Duse, M., Das, P.K., Notarangelo, L.D., Plebani, A., Badolato, R. Blood (2003) [Pubmed]
  28. Identification of the primase active site of the herpes simplex virus type 1 helicase-primase. Dracheva, S., Koonin, E.V., Crute, J.J. J. Biol. Chem. (1995) [Pubmed]
  29. Herpes simplex virus-1 helicase-primase. Physical and catalytic properties. Crute, J.J., Lehman, I.R. J. Biol. Chem. (1991) [Pubmed]
  30. Detection of antibodies to herpes simplex virus with a continuous cell line expressing cloned glycoprotein D. Berman, P.W., Dowbenko, D., Lasky, L.A., Simonsen, C.C. Science (1983) [Pubmed]
  31. Spontaneous molecular reactivation of herpes simplex virus type 1 latency in mice. Feldman, L.T., Ellison, A.R., Voytek, C.C., Yang, L., Krause, P., Margolis, T.P. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  32. A role for transforming growth factor-beta1 in the increased pneumonitis in murine allogeneic bone marrow transplant recipients with graft-versus-host disease after pulmonary herpes simplex virus type 1 infection. Adler, H., Beland, J.L., Kozlow, W., Del-Pan, N.C., Kobzik, L., Rimm, I.J. Blood (1998) [Pubmed]
  33. Phase I evaluation of 2'-fluoro-5-iodo-1-beta-D-arabinofuranosylcytosine in immunosuppressed patients with herpesvirus infection. Young, C.W., Schneider, R., Leyland-Jones, B., Armstrong, D., Tan, C.T., Lopez, C., Watanabe, K.A., Fox, J.J., Philips, F.S. Cancer Res. (1983) [Pubmed]
WikiGenes - Universities