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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

CPSF1  -  cleavage and polyadenylation specific...

Homo sapiens

Synonyms: CPSF 160 kDa subunit, CPSF160, Cleavage and polyadenylation specificity factor 160 kDa subunit, Cleavage and polyadenylation specificity factor subunit 1, HSU37012, ...
 
 
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High impact information on CPSF1

  • In Xenopus oocytes, polyadenylation of dormant mRNAs, including cyclin B1, is controlled by the cis-acting cytoplasmic polyadenylation element (CPE) and hexanucleotide AAUAAA through associations with CPEB and CPSF, respectively [1].
  • We found that CPSF is necessary for efficient splicing activity in coupled assays and that mutations in the pre-mRNA binding site of the U2 snRNP resulted in impaired splicing and in much reduced cleavage efficiency [2].

References

  1. Opposing polymerase-deadenylase activities regulate cytoplasmic polyadenylation. Kim, J.H., Richter, J.D. Mol. Cell (2006) [Pubmed]
  2. Direct interactions between subunits of CPSF and the U2 snRNP contribute to the coupling of pre-mRNA 3' end processing and splicing. Kyburz, A., Friedlein, A., Langen, H., Keller, W. Mol. Cell (2006) [Pubmed]
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