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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

ST8SIA5  -  ST8 alpha-N-acetyl-neuraminide alpha-2,8...

Homo sapiens

Synonyms: Alpha-2,8-sialyltransferase 8E, SIAT8-E, SIAT8E, ST8SiaV, Sialyltransferase 8E, ...
 
 
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High impact information on ST8SIA5

  • All blood leukocytes expressed ST8Sia IV, implicated in polysialic acid synthesis, and NK cells variably expressed high levels of ST8Sia V mRNA required for GT3 expression [1].
  • The cDNA encoding human alpha2,8-sialyltransferase (hST8Sia V) which exhibits activity toward gangliosides, GM1b, GD1a, GT1b, and GD3, was isolated by screening of human brain cDNA library with a DNA probe generated from the cDNA sequence of mouse ST8Sia V (mST8Sia V) and by 5'-RACE of mRNA from human brain tissue [2].

References

  1. Probing the cis interactions of the inhibitory receptor Siglec-7 with {alpha}2,8-disialylated ligands on natural killer cells and other leukocytes using glycan-specific antibodies and by analysis of {alpha}2,8-sialyltransferase gene expression. Avril, T., North, S.J., Haslam, S.M., Willison, H.J., Crocker, P.R. J. Leukoc. Biol. (2006) [Pubmed]
  2. Molecular cloning and expression of human alpha2,8-sialyltransferase (hST8Sia V). Kim, Y.J., Kim, K.S., Do, S., Kim, C.H., Kim, S.K., Lee, Y.C. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
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