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Gene Review

dkk1b  -  dickkopf WNT signaling pathway inhibitor 1b

Danio rerio

Synonyms: SO:0000704
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High impact information on dkk1

  • Overexpression of dkk1 promoted anterior neuroectoderm development in the embryos injected with antivin RNA, which lack most of the mesoderm and endoderm, suggesting that Dkk1 can affect regionalization of neuroectoderm independently of dorso-anterior mesendoderm [1].
  • Zebrafish Dkk1 functions in forebrain specification and axial mesendoderm formation [1].
  • The incomplete organizer in boz mutants is deficient in expression of a number of factors such as Chordin that antagonize Bone morphogenetic proteins (Bmps), and Dickkopf 1, a Wnt antagonist [2].


  1. Zebrafish Dkk1 functions in forebrain specification and axial mesendoderm formation. Hashimoto, H., Itoh, M., Yamanaka, Y., Yamashita, S., Shimizu, T., Solnica-Krezel, L., Hibi, M., Hirano, T. Dev. Biol. (2000) [Pubmed]
  2. The role of the homeodomain protein Bozozok in zebrafish axis formation. Solnica-Krezel, L., Driever, W. Int. J. Dev. Biol. (2001) [Pubmed]
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