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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

nr2f5  -  nuclear receptor subfamily 2, group F,...

Danio rerio

Synonyms: COUP, Nuclear receptor subfamily 2 group F member 5, SO:0000704, Steroid receptor homolog SVP 46, couptf, ...
 
 
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High impact information on nr2f5

  • Importantly, the COUP binding site of the arrestin gene promoter is conserved among mouse, bovine, and human [1].
  • Since COUP/ARP-1 and retinoic acid receptors (RARs/RXRs) are known to have similar DNA-binding specificities, different levels of Svp[40] might modulate retinoid signaling through competition for binding to specific RAREs in the promoters of target genes [2].
  • Svp[40] shares a particularly high degree of amino acid sequence identity (approximately 86%) with the mammalian transcription factors ARP-1 and COUP [2].

References

  1. An evolutionary conserved COUP-TF binding element in a neural-specific gene and COUP-TF expression patterns support a major role for COUP-TF in neural development. Lu, X.P., Salbert, G., Pfahl, M. Mol. Endocrinol. (1994) [Pubmed]
  2. A novel vertebrate svp-related nuclear receptor is expressed as a step gradient in developing rhombomeres and is affected by retinoic acid. Fjose, A., Weber, U., Mlodzik, M. Mech. Dev. (1995) [Pubmed]
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