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Gene Review

nr2f5  -  nuclear receptor subfamily 2, group F,...

Danio rerio

Synonyms: COUP, Nuclear receptor subfamily 2 group F member 5, SO:0000704, Steroid receptor homolog SVP 46, couptf, ...
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High impact information on nr2f5

  • Importantly, the COUP binding site of the arrestin gene promoter is conserved among mouse, bovine, and human [1].
  • Since COUP/ARP-1 and retinoic acid receptors (RARs/RXRs) are known to have similar DNA-binding specificities, different levels of Svp[40] might modulate retinoid signaling through competition for binding to specific RAREs in the promoters of target genes [2].
  • Svp[40] shares a particularly high degree of amino acid sequence identity (approximately 86%) with the mammalian transcription factors ARP-1 and COUP [2].


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