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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Arp1  -  Actin-related protein 1

Drosophila melanogaster

Synonyms: ARP1, ARP87C, Actin-like protein 1, Actin-like protein 87C, Actr87C, ...
 
 
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High impact information on Arp87C

  • An RNAi-based screen to identify the molecular mechanisms that regulate synapse retraction identified Arp-1/centractin, a subunit of the dynactin complex [1].
  • Based on amino acid sequence homology, this redox activity is probably confined to the small internal domain of the Arp protein [2].
  • We find that all three juxtapose foreign DNA sequences upstream of the Su(z)2 gene, and that at least two of these mutations (Arp1 and vgD) behave genetically as gain of function mutations in Su(z)2 [3].
  • Recently, several Arp subfamilies have been shown to be localized in the nucleus and included in protein complexes involved in the organization of chromatin structure, for example, in chromatin remodeling and histone acetyltransferase complexes [4].

References

  1. Dynactin is necessary for synapse stabilization. Eaton, B.A., Fetter, R.D., Davis, G.W. Neuron (2002) [Pubmed]
  2. The Arabidopsis thaliana apurinic endonuclease Arp reduces human transcription factors Fos and Jun. Babiychuk, E., Kushnir, S., Van Montagu, M., Inzé, D. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  3. Molecular genetics of the Posterior sex combs/Suppressor 2 of zeste region of Drosophila: aberrant expression of the Suppressor 2 of zeste gene results in abnormal bristle development. Brunk, B.P., Martin, E.C., Adler, P.N. Genetics (1991) [Pubmed]
  4. Novel actin-related proteins in vertebrates: similarities of structure and expression pattern to Arp6 localized on Drosophila heterochromatin. Kato, M., Sasaki, M., Mizuno, S., Harata, M. Gene (2001) [Pubmed]
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