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Gene Review

Arp1  -  Actin-related protein 1

Drosophila melanogaster

Synonyms: ARP1, ARP87C, Actin-like protein 1, Actin-like protein 87C, Actr87C, ...
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High impact information on Arp87C

  • An RNAi-based screen to identify the molecular mechanisms that regulate synapse retraction identified Arp-1/centractin, a subunit of the dynactin complex [1].
  • Based on amino acid sequence homology, this redox activity is probably confined to the small internal domain of the Arp protein [2].
  • We find that all three juxtapose foreign DNA sequences upstream of the Su(z)2 gene, and that at least two of these mutations (Arp1 and vgD) behave genetically as gain of function mutations in Su(z)2 [3].
  • Recently, several Arp subfamilies have been shown to be localized in the nucleus and included in protein complexes involved in the organization of chromatin structure, for example, in chromatin remodeling and histone acetyltransferase complexes [4].


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