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Gene Review

Taok3  -  TAO kinase 3

Rattus norvegicus

Synonyms: Arg357, Axotomy-related gene 357 protein, JNK/SAPK-inhibitory kinase, Jik, Jun kinase-inhibitory kinase, ...
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High impact information on JIK

  • Similar results were obtained with the conversion of Arg357 to alanine, although this mutant also diminished hydroxylase activity, and full lyase and hydroxylase activities were recovered with a lysine in this position [1].
  • These results indicate that JIK may contribute to axotomy-induced RGC death by up-regulating the expression of BH3-only protein [2].


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