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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Taok3  -  TAO kinase 3

Rattus norvegicus

Synonyms: Arg357, Axotomy-related gene 357 protein, JNK/SAPK-inhibitory kinase, Jik, Jun kinase-inhibitory kinase, ...
 
 
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High impact information on JIK

  • Similar results were obtained with the conversion of Arg357 to alanine, although this mutant also diminished hydroxylase activity, and full lyase and hydroxylase activities were recovered with a lysine in this position [1].
  • These results indicate that JIK may contribute to axotomy-induced RGC death by up-regulating the expression of BH3-only protein [2].

References

  1. Dissociation of hydroxylase and lyase activities by site-directed mutagenesis of the rat P45017 alpha. Kitamura, M., Buczko, E., Dufau, M.L. Mol. Endocrinol. (1991) [Pubmed]
  2. JNK inhibitory kinase is up-regulated in retinal ganglion cells after axotomy and enhances BimEL expression level in neuronal cells. Wakabayashi, T., Kosaka, J., Oshika, T. J. Neurochem. (2005) [Pubmed]
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