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Gene Review

TAOK3  -  TAO kinase 3

Homo sapiens

Synonyms: CTCL-associated antigen HD-CL-09, Cutaneous T-cell lymphoma-associated antigen HD-CL-09, DPK, Dendritic cell-derived protein kinase, JIK, ...
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High impact information on TAOK3

  • Furthermore, JIK kinase activity is not modulated by any exogenous stimuli, but, interestingly, it is dramatically decreased upon EGF receptor activation [1].
  • DPK expressing dominant-negative (dn)Rac1 underwent massive apoptosis upon TCR stimulation and resulted in defective differentiation of CD4-SP cells [2].
  • To assess the function of Rac1 in the differentiation process of CD4 single-positive (CD4-SP) T cells from CD4CD8 double-positive (DP) cells, we used a DP cell line DPK, which can differentiate into CD4-SP cells upon TCR stimulation in vitro [2].
  • A new, improved method is described, which takes advantage of the low solubility of potassium dodecyl sulfate (KDS), to concentrate sodium dodecyl sulfate-solubilized proteins from nanomolar solutions by KDS precipitation [3].
  • The KDS of gentamicin and tobramycin by the three dialyzers were significantly different [4].

Biological context of TAOK3

  • From dendritic cell cDNA library, we isolated a full-length cDNA encoding a potentially novel 898-residue kinase, which was designated DPK [5].
  • High-affinity binding sites (KDS ranging from 0.1 to 1 nM) have been demonstrated in brain and peripheral organs [6].

Anatomical context of TAOK3

  • Northern blotting analysis showed that DPK was ubiquitously expressed in normal tissues, with abundant expression in kidney, skeletal muscle, heart, and liver [5].
  • Total specific binding (Bmax) of the radiolabeled agonists clonidine (CLO) and para-amino-clonidine (PAC) (at concentrations above and below apparent KDS) was significantly greater in thoracic spinal cord in comparison with cervical spinal cord (P less than 0.001) [7].
  • Scatchard analysis of specific 125I-CYP binding gave KDS of 38.6 +/- 5.7 pM in DiFi cells and 54 +/- 9.1 pM in HT-29 cells [8].

Associations of TAOK3 with chemical compounds

  • Using radioligand binding techniques, we determined the equilibrium dissociation constants (KDS) for a series of antidepressants at the histamine H1, muscarinic acetylcholine, alpha-1 and alpha-2 adrenergic and dopamine (D-2) receptors of normal human brain tissue obtained at autopsy [9].
  • With the DPK data, S values for nuclei and cells with the boron-10 on the cell surface are calculated for different combinations of cell and nucleus sizes [10].
  • The surfactants were dodecyl sulfates with potassium, sodium, and lithium as counterions (KDS, NaDS, LiDS) [11].
  • From fluorescence measurements it was found that the KDS-polymer aggregates shield pyrene from water better than the other surfactants, indicating larger aggregates with a more fluid interior [11].

Other interactions of TAOK3

  • These findings suggested that DPK might be a novel candidate MAPKKK [5].

Analytical, diagnostic and therapeutic context of TAOK3

  • The relative affinities of the peptides in the placenta membrane binding assay, EGF-URO greater than TGF-alpha greater than TGF-alpha-(1-48), were in good qualitative and quantitative agreement with the LM (but not the CM) bioassay, with relative KDS in the proportions of about 1:3:17 [12].


  1. Human JIK, a novel member of the STE20 kinase family that inhibits JNK and is negatively regulated by epidermal growth factor. Tassi, E., Biesova, Z., Di Fiore, P.P., Gutkind, J.S., Wong, W.T. J. Biol. Chem. (1999) [Pubmed]
  2. Rac1-mediated Bcl-2 induction is critical in antigen-induced CD4 single-positive differentiation of a CD4+CD8+ immature thymocyte line. Oda, H., Suzuki, H., Sakai, K., Kitahara, S., Patrick, M.S., Azuma, Y., Sugi, K., Kitamura, T., Kaye, J., Shirai, M. J. Leukoc. Biol. (2007) [Pubmed]
  3. Effective recovery by KCl precipitation of highly diluted muscle proteins solubilized with sodium dodecyl sulfate. Carraro, U., Rizzi, C., Sandri, M. Electrophoresis (1991) [Pubmed]
  4. Hemodialysis elimination rates and clearance of gentamicin and tobramycin. Matzke, G.R., Halstenson, C.E., Keane, W.F. Antimicrob. Agents Chemother. (1984) [Pubmed]
  5. Cloning of DPK, a novel dendritic cell-derived protein kinase activating the ERK1/ERK2 and JNK/SAPK pathways. Zhang, W., Chen, T., Wan, T., He, L., Li, N., Yuan, Z., Cao, X. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  6. Somatostatin receptors. Lewin, M.J. Scand. J. Gastroenterol. Suppl. (1986) [Pubmed]
  7. Alpha-2-adrenergic receptors in avian spinal cord: increases in apparent density associated with the sympathetic preganglionic cell column. Cabot, J.B., Edwards, E., Bogan, N., Schechter, N. J. Auton. Nerv. Syst. (1984) [Pubmed]
  8. Characterization of beta-adrenergic receptors in DiFi and HT-29 cells. Abel, P.W., Zeng, W., Wildrick, D.M., Makoid, M.C., Boman, B.M. Anticancer Res. (1992) [Pubmed]
  9. Antagonism by antidepressants of neurotransmitter receptors of normal human brain in vitro. Richelson, E., Nelson, A. J. Pharmacol. Exp. Ther. (1984) [Pubmed]
  10. Dose point kernel for boron-11 decay and the cellular S values in boron neutron capture therapy. Ma, Y., Geng, J., Gao, S., Bao, S. Medical physics (2006) [Pubmed]
  11. Influence of counterion on the interaction of dodecyl sulfates and cellulose ethers. Ridell, A., Evertsson, H., Nilsson, S. Journal of colloid and interface science. (2002) [Pubmed]
  12. Contribution of the C-terminal dipeptide of transforming growth factor-alpha to its activity: biochemical and pharmacologic profiles. Yang, S.G., Winkler, M.E., Hollenberg, M.D. Eur. J. Pharmacol. (1990) [Pubmed]
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