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Gene Review

TAOK3  -  TAO kinase 3

Gallus gallus

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High impact information on TAOK3

  • The 898 amino acid full-length KFC protein contains an amino-terminal kinase domain, an adjacent downstream serine-rich region, and a C-terminal tail containing a coiled-coil domain [1].
  • We have also uncovered a new STE-20-related serine/threonine kinase, KFC, which is abundantly expressed in both the TGFalpha-stimulated erythroid progenitor cells and v-sea-transformed erythroblasts [2].
  • Based on sequence homology of the kinase domain, KFC appears to be the first member of a new subfamily of STE-20-like kinases [2].
  • These include McDonald's Big Mac Hamburger, Pizza Hut's Personal Pan Pizza Supreme, Kentucky Fried Chicken (KFC) three piece original recipe mixed dark and white meat luncheon package, and Häagen-Daz chocolate-chocolate chip ice cream [3].
  • Total measured PCDD/Fs in the Big Mac, Personal Pan Pizza, KFC, and the Häagen-Daz ice cream varied from 0.58 to 9.31 pg/g. Measured DDE levels in the fast foods ranged from 180 to 3170 pg/g. Total mono-ortho PCB levels ranged up to 500 pg/g or 1.28 TEQ pg/g for the KFC and for di-ortho PCBs up to 740 pg/g or 0.014 TEQ pg/g for the pizza sample [3].

Associations of TAOK3 with chemical compounds

  • Dioxin plus dibenzofuran dioxin toxic equivalents (TEQ) ranged from 0.03 to 0.28 TEQ pg/g wet or whole weight for the Big Mac, from 0.03 to 0.29 for the Pizza, from 0.01 to 0.31 for the KFC, and from 0.03 to 0.49 TEQ pg/g for the ice cream [3].


  1. KFC, a Ste20-like kinase with mitogenic potential and capability to activate the SAPK/JNK pathway. Yustein, J.T., Li, D., Robinson, D., Kung, H.J. Oncogene (2000) [Pubmed]
  2. Tyrosine kinase expression profiles of chicken erythro-progenitor cells and oncogene-transformed erythroblasts. Robinson, D., Chen, H.C., Li, D., Yustein, J.T., He, F., Lin, W.C., Hayman, M.J., Kung, H.J. J. Biomed. Sci. (1998) [Pubmed]
  3. Dioxins, dibenzofurans, dioxin-like PCBs, and DDE in U.S. fast food, 1995. Schecter, A., Li, L. Chemosphere (1997) [Pubmed]
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