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Gene Review

Sorbs1_predicted  -  sorbin and SH3 domain containing 1...

Rattus norvegicus

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High impact information on Sorbs1_predicted

  • The third proline-rich region of l-afadin bound to the region of ponsin containing the second and third SH3 domains [1].
  • Ponsin was ubiquitously expressed and localized at ZA in epithelial cells, at cell-cell AJ in nonepithelial cells, and at cell-matrix AJ in both types of cells [1].
  • This protein had a sorbin homology domain in the N terminus, a zinc finger motif in the middle region, and three src homology (SH) 3 domains in the C terminus and was homologous to the ponsin/ArgBP2/vinexin family proteins [2].
 

Biological context of Sorbs1_predicted

  • Both the two variants had three Src homology 3 (SH3) domains and turned out to be splicing variants of SH3P12 [1].

References

  1. Ponsin/SH3P12: an l-afadin- and vinculin-binding protein localized at cell-cell and cell-matrix adherens junctions. Mandai, K., Nakanishi, H., Satoh, A., Takahashi, K., Satoh, K., Nishioka, H., Mizoguchi, A., Takai, Y. J. Cell Biol. (1999) [Pubmed]
  2. nArgBP2, a novel neural member of ponsin/ArgBP2/vinexin family that interacts with synapse-associated protein 90/postsynaptic density-95-associated protein (SAPAP). Kawabe, H., Hata, Y., Takeuchi, M., Ide, N., Mizoguchi, A., Takai, Y. J. Biol. Chem. (1999) [Pubmed]
 
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