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Chemical Compound Review

sorbose     (3S,4R,5S)-1,3,4,5,6- pentahydroxyhexan-2-one

Synonyms: Esorben, Sorbinose, Sorbin, L-sorbose, L-Sor, ...
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Disease relevance of sorbose

  • C-Terminal and N-terminal antibodies disclosed sorbin in five of 14 intestinal carcinoid tumours; C-terminal antibody alone disclosed a C-terminal sorbin peptide in two of six insulinomas and three of 17 endocrine pancreatic tumours [1].
  • AIMS: To identify sorbin cells in normal human digestive tissues and to explore the expression of sorbin in 37 digestive endocrine tumours: 14 intestinal carcinoid tumours and 23 endocrine pancreatic tumours including six insulinomas [1].

High impact information on sorbose

  • The human homolog for the sorbin and SH3-domain-containing-1 gene, termed SORBS1, might play a role in human disorders with insulin resistance [2].
  • CAP contains a unique structure with three adjacent Src homology 3 (SH3) domains in the C terminus and a region showing significant sequence similarity with the peptide hormone sorbin [3].
  • This protein had a sorbin homology domain in the N terminus, a zinc finger motif in the middle region, and three src homology (SH) 3 domains in the C terminus and was homologous to the ponsin/ArgBP2/vinexin family proteins [4].
  • Presence of sorbin in human digestive tract and endocrine digestive tumours [1].
  • C-Terminal sorbin immunoreactivity alone was found in plexii from the enteric nervous system and in some insulin-containing cells of normal pancreas [1].

Biological context of sorbose


Anatomical context of sorbose


Gene context of sorbose

  • Inhibitory effect of sorbin on pepsin secretion in conscious cats and rabbits [10].

Analytical, diagnostic and therapeutic context of sorbose

  • METHODS: Two polyclonal antibodies against the C-terminal and the N-terminal sequences of porcine sorbin raised in rabbit were used to evaluate sorbin expression by immunohistochemistry [1].


  1. Presence of sorbin in human digestive tract and endocrine digestive tumours. Abou El Fadil-Nicol, F., Berger, F., Descroix-Vagne, M., Pansu, D. Gut (2000) [Pubmed]
  2. Molecular scanning of the human sorbin and SH3-domain-containing-1 (SORBS1) gene: positive association of the T228A polymorphism with obesity and type 2 diabetes. Lin, W.H., Chiu, K.C., Chang, H.M., Lee, K.C., Tai, T.Y., Chuang, L.M. Hum. Mol. Genet. (2001) [Pubmed]
  3. A novel, multifuntional c-Cbl binding protein in insulin receptor signaling in 3T3-L1 adipocytes. Ribon, V., Printen, J.A., Hoffman, N.G., Kay, B.K., Saltiel, A.R. Mol. Cell. Biol. (1998) [Pubmed]
  4. nArgBP2, a novel neural member of ponsin/ArgBP2/vinexin family that interacts with synapse-associated protein 90/postsynaptic density-95-associated protein (SAPAP). Kawabe, H., Hata, Y., Takeuchi, M., Ide, N., Mizoguchi, A., Takai, Y. J. Biol. Chem. (1999) [Pubmed]
  5. Pharmacokinetic, metabolic, and antidiarrheal properties of (D and L) heptapeptides of sorbin in rodent. Nicol, P., Vienet, R., Jourdan, G., Dumas, C., Abou el Fadil, F., Benech, H., Grognet, J.M., Tarrade, T., Pansu, D., Descroix-Vagne, M. Peptides (1995) [Pubmed]
  6. Pharmacokinetics and organ distribution of the sorbin C-terminal peptides. Nicol, P., el Fadil, F.A., Charpin, G., Jourdan, G., Dumas, C., Grognet, J.M., Tarrade, T., Pansu, D., Descroix-Vagne, M. Peptides (1994) [Pubmed]
  7. Human sorbin is generated via splicing of an alternative transcript from the ArgBP2 gene locus. Hand, D., Eiden, L.E. Peptides (2005) [Pubmed]
  8. Sorbin in the porcine gastrointestinal tract and pancreas: an immunocytochemical analysis. El Fadil, F.A., Nicol, P., Leduque, P., Berger, F., Descroix-Vagne, M., Pansu, D. Endocrinology (1997) [Pubmed]
  9. Cloning, mapping, and characterization of the human sorbin and SH3 domain containing 1 (SORBS1) gene: a protein associated with c-Abl during insulin signaling in the hepatoma cell line Hep3B. Lin, W.H., Huang, C.J., Liu, M.W., Chang, H.M., Chen, Y.J., Tai, T.Y., Chuang, L.M. Genomics (2001) [Pubmed]
  10. Inhibitory effect of sorbin on pepsin secretion in conscious cats and rabbits. Charpin-Elhamri, G., Elbaba, M., Descroix-Vagne, M., Pansu, D., Perret, J.P. Peptides (2000) [Pubmed]
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