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Gene Review

pmoA  -  methane monooxygenase subunit A

Methylococcus capsulatus str. Bath

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Disease relevance of pmoA


High impact information on pmoA

  • A 2.1-kb region was sequenced and found to contain both pmoB and a second gene, pmoA [2].
  • Three key genes: 16S rRNA; pmoA and mmoX, encoding for the particulate and soluble methane monooxygenases respectively, were cloned from the isolates and sequenced [3].

Analytical, diagnostic and therapeutic context of pmoA

  • Quantitative detection of methanotrophs in soil by novel pmoA-targeted real-time PCR assays [4].


  1. Analysis of 16S rRNA and methane monooxygenase gene sequences reveals a novel group of thermotolerant and thermophilic methanotrophs, Methylocaldum gen. nov. Bodrossy, L., Holmes, E.M., Holmes, A.J., Kovács, K.L., Murrell, J.C. Arch. Microbiol. (1997) [Pubmed]
  2. Particulate methane monooxygenase genes in methanotrophs. Semrau, J.D., Chistoserdov, A., Lebron, J., Costello, A., Davagnino, J., Kenna, E., Holmes, A.J., Finch, R., Murrell, J.C., Lidstrom, M.E. J. Bacteriol. (1995) [Pubmed]
  3. Diversity of soluble methane monooxygenase-containing methanotrophs isolated from polluted environments. McDonald, I.R., Miguez, C.B., Rogge, G., Bourque, D., Wendlandt, K.D., Groleau, D., Murrell, J.C. FEMS Microbiol. Lett. (2006) [Pubmed]
  4. Quantitative detection of methanotrophs in soil by novel pmoA-targeted real-time PCR assays. Kolb, S., Knief, C., Stubner, S., Conrad, R. Appl. Environ. Microbiol. (2003) [Pubmed]
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