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Gene Review

mmoX  -  methane monooxygenase subunit A, alpha chain

Methylococcus capsulatus str. Bath

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Disease relevance of mmoX

  • One of them exhibited high identity to the mmoX protein of the Methylocystis-Methylosinus group, whereas the other showed an equal level of divergence from both the Methylosinus-Methylocystis group and Methylococcus capsulatus (Bath) and formed a distinct branch [1].
  • Duplication of the mmoX gene in Methylosinus sporium: cloning, sequencing and mutational analysis [2].

High impact information on mmoX

  • DNA from each enrichment yielded a PCR product of the expected size with primers for both mmoX and mmoY genes of soluble methane monooxygenase [1].
  • These new isolates exhibit a DNA sequence homology of up to 97% with the conserved regions in the mmoX and mmoC genes of the soluble methane monooxygenase (MMO)-coding gene cluster of Methylococcus capsulatus Bath [3].
  • We now report the complete nucleotide (nt) sequence of mmoX, the gene encoding the alpha-subunit of component A which is found to be 5' to mmoY and mmoZ [4].
  • The promoter region of mmoX was mapped using truncated 5' end regions fused to a promoterless green fluorescent protein gene [5].
  • Three key genes: 16S rRNA; pmoA and mmoX, encoding for the particulate and soluble methane monooxygenases respectively, were cloned from the isolates and sequenced [6].


  1. Acidophilic methanotrophic communities from Sphagnum peat bogs. Dedysh, S.N., Panikov, N.S., Tiedje, J.M. Appl. Environ. Microbiol. (1998) [Pubmed]
  2. Duplication of the mmoX gene in Methylosinus sporium: cloning, sequencing and mutational analysis. Ali, H., Scanlan, J., Dumont, M.G., Murrell, J.C. Microbiology (Reading, Engl.) (2006) [Pubmed]
  3. Heat-tolerant methanotrophic bacteria from the hot water effluent of a natural gas field. Bodrossy, L., Murrell, J.C., Dalton, H., Kalman, M., Puskas, L.G., Kovacs, K.L. Appl. Environ. Microbiol. (1995) [Pubmed]
  4. The methane monooxygenase gene cluster of Methylococcus capsulatus (Bath). Stainthorpe, A.C., Lees, V., Salmond, G.P., Dalton, H., Murrell, J.C. Gene (1990) [Pubmed]
  5. Genes involved in the copper-dependent regulation of soluble methane monooxygenase of Methylococcus capsulatus (Bath): cloning, sequencing and mutational analysis. Csáki, R., Bodrossy, L., Klem, J., Murrell, J.C., Kovács, K.L. Microbiology (Reading, Engl.) (2003) [Pubmed]
  6. Diversity of soluble methane monooxygenase-containing methanotrophs isolated from polluted environments. McDonald, I.R., Miguez, C.B., Rogge, G., Bourque, D., Wendlandt, K.D., Groleau, D., Murrell, J.C. FEMS Microbiol. Lett. (2006) [Pubmed]
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