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Gene Review:

mmoX - methane monooxygenase subunit A, alpha chain

Methylococcus capsulatus str. Bath

Dedysh, S.N. et al., Bodrossy, L. et al., McDonald, I.R. et al., Stainthorpe, A.C. et al., Csáki, R. et al., et al.

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Disease relevance of mmoX

One of them exhibited high identity to the mmoX protein of the Methylocystis-Methylosinus group, whereas the other showed an equal level of divergence from both the Methylosinus-Methylocystis group and Methylococcus capsulatus (Bath) and formed a distinct branch [1].
Duplication of the mmoX gene in Methylosinus sporium: cloning, sequencing and mutational analysis [2].

High impact information on mmoX

DNA from each enrichment yielded a PCR product of the expected size with primers for both mmoX and mmoY genes of soluble methane monooxygenase [1].
These new isolates exhibit a DNA sequence homology of up to 97% with the conserved regions in the mmoX and mmoC genes of the soluble methane monooxygenase (MMO)-coding gene cluster of Methylococcus capsulatus Bath [3].
We now report the complete nucleotide (nt) sequence of mmoX, the gene encoding the alpha-subunit of component A which is found to be 5' to mmoY and mmoZ [4].
The promoter region of mmoX was mapped using truncated 5' end regions fused to a promoterless green fluorescent protein gene [5].
Three key genes: 16S rRNA; pmoA and mmoX, encoding for the particulate and soluble methane monooxygenases respectively, were cloned from the isolates and sequenced [6].

References

Acidophilic methanotrophic communities from Sphagnum peat bogs. Dedysh, S.N., Panikov, N.S., Tiedje, J.M. Appl. Environ. Microbiol. (1998) [Pubmed]
Duplication of the mmoX gene in Methylosinus sporium: cloning, sequencing and mutational analysis. Ali, H., Scanlan, J., Dumont, M.G., Murrell, J.C. Microbiology (Reading, Engl.) (2006) [Pubmed]
Heat-tolerant methanotrophic bacteria from the hot water effluent of a natural gas field. Bodrossy, L., Murrell, J.C., Dalton, H., Kalman, M., Puskas, L.G., Kovacs, K.L. Appl. Environ. Microbiol. (1995) [Pubmed]
The methane monooxygenase gene cluster of Methylococcus capsulatus (Bath). Stainthorpe, A.C., Lees, V., Salmond, G.P., Dalton, H., Murrell, J.C. Gene (1990) [Pubmed]
Genes involved in the copper-dependent regulation of soluble methane monooxygenase of Methylococcus capsulatus (Bath): cloning, sequencing and mutational analysis. Csáki, R., Bodrossy, L., Klem, J., Murrell, J.C., Kovács, K.L. Microbiology (Reading, Engl.) (2003) [Pubmed]
Diversity of soluble methane monooxygenase-containing methanotrophs isolated from polluted environments. McDonald, I.R., Miguez, C.B., Rogge, G., Bourque, D., Wendlandt, K.D., Groleau, D., Murrell, J.C. FEMS Microbiol. Lett. (2006) [Pubmed]

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