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Disease relevance of Methylomonas

  • In addition, methanol oxidation genes have been studied in an autotrophic methanol-utilizer (Paracoccus denitrificans) and three methanotrophs (Methylosporovibrio methanica, Methylomonas albus and Methylomonas sp. A4) [1].
  • We now have discovered that the KGPDC from E. coli and the HPS from Methylomonas aminofaciens are both naturally promiscuous for the reaction catalyzed by the homologue [2].
  • The nonpolar lipids of methanol-grown bacteria which utilize one-carbon (C1) compounds via the RMP pathway (Pseudomonas C, Pseudomonas methylotropha, and Methylomonas methanolica) were found to contain squalene in concentrations between 0.1 to 1.16 mg/g of cell (dry weight) [3].
  • No pmoA2 was detected in five type I MOB tested: Methylococcus capsulatus strain Bath, Methylocaldum strain E10A, Methylobacter luteus, Methylomicrobium album, and Methylomonas strain D1a [4].
  • Gene probing using cyp indicated that a cytochrome P460 similar to that from M. capsulatus Bath may be present in the type II methanotrophs Methylosinus trichosporium OB3b and Methylocystis parvus OBBP but not in the type I methanotrophs Methylobacter marinus A45, Methylomicrobium albus BG8, and Methylomonas sp. strains MN and MM2 [5].

High impact information on Methylomonas


Chemical compound and disease context of Methylomonas

  • Formate, provided as an exogenous electron donor, increased TCE transformation rates in Methylomonas sp. strain MM2, but not in mixed culture MM1 or unidentified isolate, CSC-1 [11].
  • An aldehyde dehydrogenase gene (ald) responsible for the subsequent oxidation of 4,4'-diapolycopene aldehyde to 4,4'-diapolycopene acid was also identified in Methylomonas [10].
  • In contrast, activity of pMMO in M. trichosporium OB3b, M. capsulatus Bath, Methylomicrobium album BG8, Methylobacter marinus A45 and Methylomonas strain MN was still measurable at phenylacetylene concentrations up to 1,000 microM [12].
  • Inhibition of trichloroethylene (TCE) oxidation by the transformation intermediate carbon monoxide (CO) was evaluated with the aquifer methanotroph Methylomonas sp. strain MM2 [13].
  • 3-Hexulosephosphate synthase, the first enzyme of the ribulose monophosphate cycle, was purified 15-fold from methanol-grown Methylomonas M 15 [14].

Biological context of Methylomonas


Gene context of Methylomonas

  • A probe consisting of the 3'-end of the mopB gene hybridized to the type I methanotroph Methylomonas methanica S in Southern blots containing DNA from nine methanotrophic strains representing six different genera [16].
  • CO at a concentration greater than that used in the inhibition studies was not toxic to Methylomonas sp. strain MM2 [13].
  • Purification and regulation of glucose-6-phosphate dehydrogenase from obligate methanol-utilizing bacterium Methylomonas M15 [17].
  • In view of these properties and in view of the fact that the protein is active as an electron carrier between methylamine dehydrogenase and cytochrome c, it is concluded that it is similar to the amicyanins isolated from Methylomonas sp. strain J and Pseudomonas sp. strain AM 1 [18].
  • We propose that strains OR2 and LK6, together with the misclassified thermophilic strains Methylomonas gracilis VKM-14LT and Methylococcus thermophilus IMV-B3122, comprise a new genus of thermophilic methanotrophs, Methylocaldum gen. nov., containing three new species: Methylocaldum szegediense, Methylocaldum tepidum and Methylocaldum gracile [19].

Analytical, diagnostic and therapeutic context of Methylomonas


  1. Genetics of carbon metabolism in methylotrophic bacteria. Lidstrom, M.E. FEMS Microbiol. Rev. (1990) [Pubmed]
  2. Evolution of enzymatic activities in the orotidine 5'-monophosphate decarboxylase suprafamily: enhancing the promiscuous D-arabino-hex-3-ulose 6-phosphate synthase reaction catalyzed by 3-keto-L-gulonate 6-phosphate decarboxylase. Yew, W.S., Akana, J., Wise, E.L., Rayment, I., Gerlt, J.A. Biochemistry (2005) [Pubmed]
  3. Occurrence of squalene in methanol-grown bacteria. Goldberg, I., Shechter, I. J. Bacteriol. (1978) [Pubmed]
  4. Wide distribution of a novel pmoA-like gene copy among type II methanotrophs, and its expression in Methylocystis strain SC2. Tchawa Yimga, M., Dunfield, P.F., Ricke, P., Heyer, J., Liesack, W. Appl. Environ. Microbiol. (2003) [Pubmed]
  5. Cytochrome P460 genes from the methanotroph Methylococcus capsulatus bath. Bergmann, D.J., Zahn, J.A., Hooper, A.B., DiSpirito, A.A. J. Bacteriol. (1998) [Pubmed]
  6. The significance of the flexible loop in the azurin (Az-iso2) from the obligate methylotroph Methylomonas sp. strain J. Inoue, T., Suzuki, S., Nishio, N., Yamaguchi, K., Kataoka, K., Tobari, J., Yong, X., Hamanaka, S., Matsumura, H., Kai, Y. J. Mol. Biol. (2003) [Pubmed]
  7. Iron- and manganese-containing superoxide dismutases from Methylomonas J: identity of the protein moiety and amino acid sequence. Matsumoto, T., Terauchi, K., Isobe, T., Matsuoka, K., Yamakura, F. Biochemistry (1991) [Pubmed]
  8. The respiratory chain of a newly isolated Methylomonas Pl1. Drabikowska, A.K. Biochem. J. (1977) [Pubmed]
  9. An improved assay for bacterial methane mono-oxygenase: some properties of the enzyme from Methylomonas methanica. Colby, J., Dalton, H., Whittenbury, R. Biochem. J. (1975) [Pubmed]
  10. Novel carotenoid oxidase involved in biosynthesis of 4,4'-diapolycopene dialdehyde. Tao, L., Schenzle, A., Odom, J.M., Cheng, Q. Appl. Environ. Microbiol. (2005) [Pubmed]
  11. Influence of endogenous and exogenous electron donors and trichloroethylene oxidation toxicity on trichloroethylene oxidation by methanotrophic cultures from a groundwater aquifer. Henry, S.M., Grbić-Galić, D. Appl. Environ. Microbiol. (1991) [Pubmed]
  12. Differential inhibition in vivo of ammonia monooxygenase, soluble methane monooxygenase and membrane-associated methane monoxygenase by phenylacetylene. Lontoh, S., DiSpirito, A.A., Krema, C.L., Whittaker, M.R., Hooper, A.B., Semrau, J.D. Environ. Microbiol. (2000) [Pubmed]
  13. Inhibition of trichloroethylene oxidation by the transformation intermediate carbon monoxide. Henry, S.M., Grbić-Galić, D. Appl. Environ. Microbiol. (1991) [Pubmed]
  14. Purification and properties of 3-hexulosephosphate synthase from Methylomonas M 15. Sahm, H., Schütte, H., Kula, M.R. Eur. J. Biochem. (1976) [Pubmed]
  15. Cloning and characterization of the azurin iso-1 gene, concerned with the electron transport chain involved in methylamine/methanol oxidation in the obligate methylotroph Methylomonas sp. strain J. Taguchi, K., Kudo, T., Tobari, J. Biosci. Biotechnol. Biochem. (1998) [Pubmed]
  16. Molecular analysis of an outer membrane protein, MopB, of Methylococcus capsulatus (Bath) and structural comparisons with proteins of the OmpA family. Fjellbirkeland, A., Bemanian, V., McDonald, I.R., Murrell, J.C., Jensen, H.B. Arch. Microbiol. (2000) [Pubmed]
  17. Purification and regulation of glucose-6-phosphate dehydrogenase from obligate methanol-utilizing bacterium Methylomonas M15. Steinbach, R.A., Sahm, H., Schütte, H. Eur. J. Biochem. (1978) [Pubmed]
  18. Isolation and characterization of a blue copper protein from Thiobacillus versutus. van Houwelingen, T., Canters, G.W., Stobbelaar, G., Duine, J.A., Frank, J., Tsugita, A. Eur. J. Biochem. (1985) [Pubmed]
  19. Analysis of 16S rRNA and methane monooxygenase gene sequences reveals a novel group of thermotolerant and thermophilic methanotrophs, Methylocaldum gen. nov. Bodrossy, L., Holmes, E.M., Holmes, A.J., Kovács, K.L., Murrell, J.C. Arch. Microbiol. (1997) [Pubmed]
  20. Methanol dehydrogenase of Methylomonas J: purification, crystallization, and some properties. Ohta, S., Fujita, T., Tobari, J. J. Biochem. (1981) [Pubmed]
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