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Gene Review

pmoA2  -  methane monooxygenase subunit A

Methylococcus capsulatus str. Bath

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Disease relevance of pmoA2

  • No pmoA2 was detected in five type I MOB tested: Methylococcus capsulatus strain Bath, Methylocaldum strain E10A, Methylobacter luteus, Methylomicrobium album, and Methylomonas strain D1a [1].

High impact information on pmoA2

  • However, screening by PCR and by Southern hybridization using a newly developed pmoA2-specific oligonucleotide probe also showed that closely related type II MOB, exhibiting 16S rRNA gene sequence identities of higher than 97%, may or may not harbor pmoA2 [1].
  • Null mutants were obtained for pmoC1, pmoC2, pmoA1, pmoA2, pmoB1 and pmoB2 [2].

Analytical, diagnostic and therapeutic context of pmoA2

  • In comparative sequence analyses, all pmoA2-like sequences formed a coherent cluster clearly distinct from pmoA1 sequences of type I and type II MOB, and from amoA sequences of the Nitrosomonas-Nitrosospira group [1].


  1. Wide distribution of a novel pmoA-like gene copy among type II methanotrophs, and its expression in Methylocystis strain SC2. Tchawa Yimga, M., Dunfield, P.F., Ricke, P., Heyer, J., Liesack, W. Appl. Environ. Microbiol. (2003) [Pubmed]
  2. Role of multiple gene copies in particulate methane monooxygenase activity in the methane-oxidizing bacterium Methylococcus capsulatus Bath. Stolyar, S., Costello, A.M., Peeples, T.L., Lidstrom, M.E. Microbiology (Reading, Engl.) (1999) [Pubmed]
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