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Gene Review:

flaA - flagellin

Legionella pneumophila str. Paris

Akamine, M. et al.

Akamine, Higa, Haranaga, Tateyama, Mori, Heuner, Fujita,

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High impact information on flaA

Cell viability was not impaired until 3 days after infection when the flaA mutant bacteria replicated 10(2-3)-fold in macrophages, implying that L. pneumophila inhibited host cell death during the early phase of intracellular replication [1].

Anatomical context of flaA

The flaA mutant L. pneumophila multiplied within C57BL/6 and BALB/c macrophages while the wild-type strain did not [1].

References

Interferon-Gamma Reverses the Evasion of Birc1e/Naip5 Gene Mediated Murine Macrophage Immunity by Legionella pneumophila Mutant Lacking Flagellin. Akamine, M., Higa, F., Haranaga, S., Tateyama, M., Mori, N., Heuner, K., Fujita, J. Microbiol. Immunol. (2007) [Pubmed]

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