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Gene Review:

HLA-DRB6 - major histocompatibility complex, class II...

Homo sapiens

Fernandez-Soria, V.M. et al., Ringquist, S. et al., Mayer, W.E. et al., Corell, A. et al., Corell, A. et al.

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High impact information on HLA-DRB6

HLA-DRB6, one of the human major histocompatibility complex genes, lacks exon 1, which normally codes for the leader and the first four amino acid residues of the mature protein [1].
Pyrosequencing primers were designed to specifically sequence HLA loci of interest even in a background of other amplified, closely related sequences such as alleles of the pseudogene HLA-DRB6, -7, -8, and -9 [2].
HLA-DRB6 is one of the human major histocompatibility complex (MHC) genes present in DR1, DR2, and DR10 haplotypes (approximately 26% of individuals) [3].
Finally, the presence of mature HLA-DRB6 mRNA molecules supports the notion that splicing may take place even in the absence of a canonical 3'UT polyadenylation signal [3].
The HLA-DRB6 locus defines an evolutionary supratypic group within the DRB family of genes [4].

Associations of HLA-DRB6 with chemical compounds

The HLA-DRB6 gene (also called DRB sigma/V1) has been found only in about 26% of human HLA haplotypes, i.e.; DR1, DRw10, and DR2-bearing ones (Corell et al. 1991) [5].

References

Resolution of the HLA-DRB6 puzzle: a case of grafting a de novo-generated exon on an existing gene. Mayer, W.E., O'hUigin, C., Klein, J. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
HLA class II DRB high resolution genotyping by pyrosequencing: comparison of group specific PCR and pyrosequencing primers. Ringquist, S., Alexander, A.M., Styche, A., Pecoraro, C., Rudert, W.A., Trucco, M. Hum. Immunol. (2004) [Pubmed]
Transcription and weak expression of HLA-DRB6: a gene with anomalies in exon 1 and other regions. Fernandez-Soria, V.M., Morales, P., Castro, M.J., Suarez, B., Recio, M.J., Moreno, M.A., Paz-Artal, E., Arnaiz-Villena, A. Immunogenetics (1998) [Pubmed]
The HLA-DRB6 locus defines an evolutionary supratypic group within the DRB family of genes. Corell, A., Martin-Villa, J.M., Morales, P., de Juan, M.D., Vicario, J.L., Martínez-Laso, J., Varela, P., Arnaiz-Villena, A. Int. J. Cancer Suppl. (1991) [Pubmed]
Allelic diversity at the primate major histocompatibility complex DRB6 locus. Corell, A., Morales, P., Varela, P., Paz-Artal, E., Martin-Villa, J.M., Martinez-Laso, J., Arnaiz-Villena, A. Immunogenetics (1992) [Pubmed]

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