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Chemical Compound Review

DRB     (2R,3R,4S,5R)-2-(5,6- dichlorobenzoimidazol...

Synonyms: SureCN62273, CHEMBL375530, CHEBI:49852, D1916_SIGMA, LS-32834, ...
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Disease relevance of Dichlororibofuranosylbenzimidazole


Psychiatry related information on Dichlororibofuranosylbenzimidazole

  • The amnesia was distinguishable from that reported in patients HM and DRB and shared features with that seen in patients with Korsakoff's syndrome [6].

High impact information on Dichlororibofuranosylbenzimidazole


Chemical compound and disease context of Dichlororibofuranosylbenzimidazole


Biological context of Dichlororibofuranosylbenzimidazole


Anatomical context of Dichlororibofuranosylbenzimidazole

  • One major B cell epitope, located within the region corresponding to amino acid residues 74-248, was perfectly associated with the amino acid sequence FLEDR at positions 67-71 in the beta 1 domain of the DRB gene [18].
  • Preliminary mRNA turnover experiments in which 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole was used to inhibit mRNA synthesis suggest that these mRNAs are much more stable in the adipocyte cytoplasm than the other mRNAs examined [19].
  • We show that HLA oligotyping, performed on 50 pairs of HLA class I and II serologically matched individuals, can indeed reveal phenotypically relevant allelic differences at either DRB or DQB loci in 56% of these pairs and can therefore improve HLA class II typing and the choice of bone marrow donors quite significantly [20].
  • The nucleoside analogue 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole, a selective inhibitor of heterogeneous chromosomal RNA synthesis in salivary gland cells of the midge Chironomus tentans, blocks the initiation of transcription in Balbiani rings 1 and 2 [21].
  • Oligotyping for DRB/DQB/DPB polymorphism also allows prediction of a positive mixed lymphocyte culture, as established in 31 donor/recipient combinations, and even detection of polymorphic differences that were not revealed by this test [20].

Associations of Dichlororibofuranosylbenzimidazole with other chemical compounds

  • The kinetics of transcript release from the site of transcription was assessed by treatment of cells with the transcriptional inhibitors actinomycin D, alpha-amanitin and DRB [22].
  • Transcription of the Balbiani ring (BR) genes of the dipteran Chironomus tentans was inhibited by teh nucleoside analogue DRB (5,6-dichloro-1-beta-D-ribofuranosyl benzimidazole) [23].
  • The capacity of flavopiridol to promote bortezomib-mediated Bcr/Abl down-regulation and apoptosis was mimicked by the positive transcription elongation factor-b (P-TEFb) inhibitor DRB (5,6-dichloro 1-beta-d-ribofuranosylbenzinida-sole) [24].
  • Intron 1 segments of 24 DRB genes from five platyrrhine species and five DRB genes from three prosimian species were amplified by PCR and cloned, and the amplification products were sequenced or PCR-typed for Alu repeats [25].
  • Antibody 9.6 did not prevent IL 2 mRNA superinduction induced by cycloheximide, whereas CsA, as well as transcription inhibitor DRB, completely blocked this phenomenon [26].

Gene context of Dichlororibofuranosylbenzimidazole

  • Chase experiments with the dephosphorylated elongation transcription complexes were performed in the presence of the CDK9 kinase inhibitor DRB (5,6-dichloro-1-beta-D-ribofuranosyl-benzimidazole) [27].
  • MICA and MICB genes are found in the class I region between HLA-B and DRB [28].
  • The ds/dn ratios for DQA1 and DQB1 alleles are lower than for the most polymorphic DRB genes [29].
  • For DRB loci, nonsynonymous changes were found to exceed synonymous changes at HLA-DRB1, DRB3 and DRB5, while no evidence of deviations from equal rates of synonymous and nonsynonymous substitutions were found for DRB6 [29].
  • The aim of this study was to compare the transcriptional activities of the promoters of the DRB genes and DRB1 alleles in a transient expression system [30].

Analytical, diagnostic and therapeutic context of Dichlororibofuranosylbenzimidazole


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  7. NELF, a multisubunit complex containing RD, cooperates with DSIF to repress RNA polymerase II elongation. Yamaguchi, Y., Takagi, T., Wada, T., Yano, K., Furuya, A., Sugimoto, S., Hasegawa, J., Handa, H. Cell (1999) [Pubmed]
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  12. Regulation of interleukin-8 expression by reduced oxygen pressure in human glioblastoma. Desbaillets, I., Diserens, A.C., de Tribolet, N., Hamou, M.F., Van Meir, E.G. Oncogene (1999) [Pubmed]
  13. Heme catabolism in liver cirrhosis with portal hypertension after shunt surgery. Mercke, C., Lundh, B., Bengmark, S., Börjesson, B., Simert, G., Vang, J. Scand. J. Gastroenterol. (1977) [Pubmed]
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  15. NF-kappaB binds P-TEFb to stimulate transcriptional elongation by RNA polymerase II. Barboric, M., Nissen, R.M., Kanazawa, S., Jabrane-Ferrat, N., Peterlin, B.M. Mol. Cell (2001) [Pubmed]
  16. The T cell response of HLA-DR transgenic mice to human myelin basic protein and other antigens in the presence and absence of human CD4. Altmann, D.M., Douek, D.C., Frater, A.J., Hetherington, C.M., Inoko, H., Elliott, J.I. J. Exp. Med. (1995) [Pubmed]
  17. Differences in gene copy number carried by different MHC ancestral haplotypes. Quantitation after physical separation of haplotypes by pulsed field gel electrophoresis. Zhang, W.J., Degli-Esposti, M.A., Cobain, T.J., Cameron, P.U., Christiansen, F.T., Dawkins, R.L. J. Exp. Med. (1990) [Pubmed]
  18. The HLA-DR and DQ genes control the autoimmune response to DNA topoisomerase I in systemic sclerosis (scleroderma). Kuwana, M., Kaburaki, J., Okano, Y., Inoko, H., Tsuji, K. J. Clin. Invest. (1993) [Pubmed]
  19. Developmentally regulated mRNAs in 3T3-adipocytes: analysis of transcriptional control. Cook, K.S., Hunt, C.R., Spiegelman, B.M. J. Cell Biol. (1985) [Pubmed]
  20. Selection of unrelated donors for bone marrow transplantation is improved by HLA class II genotyping with oligonucleotide hybridization. Tiercy, J.M., Morel, C., Freidel, A.C., Zwahlen, F., Gebuhrer, L., Bétuel, H., Jeannet, M., Mach, B. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  21. Inhibition of Balbiani ring RNA synthesis at the initiation level. Egyházi, E. Proc. Natl. Acad. Sci. U.S.A. (1975) [Pubmed]
  22. Inefficient processing impairs release of RNA from the site of transcription. Custódio, N., Carmo-Fonseca, M., Geraghty, F., Pereira, H.S., Grosveld, F., Antoniou, M. EMBO J. (1999) [Pubmed]
  23. Packing of a specific gene into higher order structures following repression of RNA synthesis. Andersson, K., Björkroth, B., Daneholt, B. J. Cell Biol. (1984) [Pubmed]
  24. Bortezomib and flavopiridol interact synergistically to induce apoptosis in chronic myeloid leukemia cells resistant to imatinib mesylate through both Bcr/Abl-dependent and -independent mechanisms. Dai, Y., Rahmani, M., Pei, X.Y., Dent, P., Grant, S. Blood (2004) [Pubmed]
  25. Alu elements support independent origin of prosimian, platyrrhine, and catarrhine Mhc-DRB genes. Kriener, K., O'hUigin, C., Klein, J. Genome Res. (2000) [Pubmed]
  26. Down regulation of IL 2 mRNA by antibody to the 50-kd protein associated with E receptors on human T lymphocyte. Tadmori, W., Kant, J.A., Kamoun, M. J. Immunol. (1986) [Pubmed]
  27. Phosphorylation of the RNA polymerase II carboxyl-terminal domain by CDK9 is directly responsible for human immunodeficiency virus type 1 Tat-activated transcriptional elongation. Kim, Y.K., Bourgeois, C.F., Isel, C., Churcher, M.J., Karn, J. Mol. Cell. Biol. (2002) [Pubmed]
  28. Primary sclerosing cholangitis is associated to an extended B8-DR3 haplotype including particular MICA and MICB alleles. Wiencke, K., Spurkland, A., Schrumpf, E., Boberg, K.M. Hepatology (2001) [Pubmed]
  29. Evolution of Mhc class II polymorphism: the rise and fall of class II gene function in primates. Bergström, T., Gyllensten, U. Immunol. Rev. (1995) [Pubmed]
  30. Differential transcriptional activities of HLA-DR genes in the various haplotypes. Louis, P., Vincent, R., Cavadore, P., Clot, J., Eliaou, J.F. J. Immunol. (1994) [Pubmed]
  31. Distinct properties of c-myc transcriptional elongation are revealed in Xenopus oocytes and mammalian cells and by template titration, 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB), and promoter mutagenesis. Meulia, T., Krumm, A., Groudine, M. Mol. Cell. Biol. (1993) [Pubmed]
  32. Expansion and contraction of rhesus macaque DRB regions by duplication and deletion. Slierendregt, B.L., Otting, N., van Besouw, N., Jonker, M., Bontrop, R.E. J. Immunol. (1994) [Pubmed]
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