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Gene Review

Tip60  -  CG6121 gene product from transcript CG6121-RA

Drosophila melanogaster

Synonyms: 6121, CG6121, DmEG0007.7, Dmel/TIP60, Dmel\CG6121, ...
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High impact information on Tip60

  • These findings provide evidence for a gene dosage-dependent interaction between the esc/E(z) complex and the Tip60 histone acetyltransferase complex [1].
  • Additionally, in Drosophila, Tip60 exchanges gamma-H2AX for unmodified H2A in regions of DNA damage [2].
  • Acetylation by Tip60 is required for selective histone variant exchange at DNA lesions [3].


  1. Mutations in the extra sex combs and Enhancer of Polycomb Genes Increase Homologous Recombination in Somatic Cells of Drosophila melanogaster. Holmes, A.M., Weedmark, K.A., Gloor, G.B. Genetics (2006) [Pubmed]
  2. DNA repair in the context of chromatin. Morrison, A.J., Shen, X. Cell Cycle (2005) [Pubmed]
  3. Acetylation by Tip60 is required for selective histone variant exchange at DNA lesions. Kusch, T., Florens, L., Macdonald, W.H., Swanson, S.K., Glaser, R.L., Yates, J.R., Abmayr, S.M., Washburn, M.P., Workman, J.L. Science (2004) [Pubmed]
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