Gene Review:
KAT5 - K(lysine) acetyltransferase 5
Homo sapiens
Synonyms:
60 kDa Tat-interactive protein, ESA1, HIV-1 Tat interactive protein, HTATIP, HTATIP1, ...
- Homeodomain-interacting protein kinase-2 restrains cytosolic phospholipase A2-dependent prostaglandin E2 generation in human colorectal cancer cells. D'Orazi, G., Sciulli, M.G., Di Stefano, V., Riccioni, S., Frattini, M., Falcioni, R., Bertario, L., Sacchi, A., Patrignani, P. Clin. Cancer Res. (2006)
- Control of the histone-acetyltransferase activity of Tip60 by the HIV-1 transactivator protein, Tat. Creaven, M., Hans, F., Mutskov, V., Col, E., Caron, C., Dimitrov, S., Khochbin, S. Biochemistry (1999)
- Expression and function of androgen receptor coactivators in prostate cancer. Culig, Z., Comuzzi, B., Steiner, H., Bartsch, G., Hobisch, A. J. Steroid Biochem. Mol. Biol. (2004)
- Tip60 is required for DNA interstrand cross-link repair in the Fanconi anemia pathway. Hejna, J., Holtorf, M., Hines, J., Mathewson, L., Hemphill, A., Al-Dhalimy, M., Olson, S.B., Moses, R.E. J. Biol. Chem. (2008)
- BanI polymorphism of the cytosolic phospholipase A2 gene and mood disorders in the Korean population. Pae, C.U., Yu, H.S., Kim, J.J., Lee, C.U., Lee, S.J., Lee, K.U., Jun, T.Y., Paik, I.H., Serretti, A., Lee, C. Neuropsychobiology (2004)
- Cytosolic phospholipase A2 (cPLA2) immunoreactivity is elevated in Alzheimer's disease brain. Stephenson, D.T., Lemere, C.A., Selkoe, D.J., Clemens, J.A. Neurobiol. Dis. (1996)
- Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein. Baek, S.H., Ohgi, K.A., Rose, D.W., Koo, E.H., Glass, C.K., Rosenfeld, M.G. Cell (2002)
- Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis. Ikura, T., Ogryzko, V.V., Grigoriev, M., Groisman, R., Wang, J., Horikoshi, M., Scully, R., Qin, J., Nakatani, Y. Cell (2000)
- Crystal structure of human cytosolic phospholipase A2 reveals a novel topology and catalytic mechanism. Dessen, A., Tang, J., Schmidt, H., Stahl, M., Clark, J.D., Seehra, J., Somers, W.S. Cell (1999)
- cPLA2 is phosphorylated and activated by MAP kinase. Lin, L.L., Wartmann, M., Lin, A.Y., Knopf, J.L., Seth, A., Davis, R.J. Cell (1993)
- Hydrogen peroxide generated at the level of mitochondria in response to peroxynitrite promotes U937 cell death via inhibition of the cytoprotective signalling mediated by cytosolic phospholipase A2. Tommasini, I., Sestili, P., Guidarelli, A., Cantoni, O. Cell Death Differ. (2004)
- Independent folding and ligand specificity of the C2 calcium-dependent lipid binding domain of cytosolic phospholipase A2. Nalefski, E.A., McDonagh, T., Somers, W., Seehra, J., Falke, J.J., Clark, J.D. J. Biol. Chem. (1998)
- Cytosolic phospholipase A2 is coupled to muscarinic receptors in the human astrocytoma cell line 1321N1: characterization of the transducing mechanism. Bayon, Y., Hernandez, M., Alonso, A., Nuñez, L., Garcia-Sancho, J., Leslie, C., Sanchez Crespo, M., Nieto, M.L. Biochem. J. (1997)
- Differential stimulation of cytosolic phospholipase A2 by bradykinin in human cystic fibrosis cell lines. Berguerand, M., Klapisz, E., Thomas, G., Humbert, L., Jouniaux, A.M., Olivier, J.L., Béréziat, G., Masliah, J. Am. J. Respir. Cell Mol. Biol. (1997)
- Tip60 and p400 are both required for UV-induced apoptosis but play antagonistic roles in cell cycle progression. Tyteca, S., Vandromme, M., Legube, G., Chevillard-Briet, M., Trouche, D. EMBO J. (2006)
- Acetylation of the p53 DNA-binding domain regulates apoptosis induction. Sykes, S.M., Mellert, H.S., Holbert, M.A., Li, K., Marmorstein, R., Lane, W.S., McMahon, S.B. Mol. Cell (2006)
- Dual regulation of c-Myc by p300 via acetylation-dependent control of Myc protein turnover and coactivation of Myc-induced transcription. Faiola, F., Liu, X., Lo, S., Pan, S., Zhang, K., Lymar, E., Farina, A., Martinez, E. Mol. Cell. Biol. (2005)
- GAS41 is required for repression of the p53 tumor suppressor pathway during normal cellular proliferation. Park, J.H., Roeder, R.G. Mol. Cell. Biol. (2006)
- PLIP, a novel splice variant of Tip60, interacts with group IV cytosolic phospholipase A(2), induces apoptosis, and potentiates prostaglandin production. Sheridan, A.M., Force, T., Yoon, H.J., O'Leary, E., Choukroun, G., Taheri, M.R., Bonventre, J.V. Mol. Cell. Biol. (2001)
- Tip60 is targeted to proteasome-mediated degradation by Mdm2 and accumulates after UV irradiation. Legube, G., Linares, L.K., Lemercier, C., Scheffner, M., Khochbin, S., Trouche, D. EMBO J. (2002)
- The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60 histone acetyltransferase and SRCAP complexes. Cai, Y., Jin, J., Florens, L., Swanson, S.K., Kusch, T., Li, B., Workman, J.L., Washburn, M.P., Conaway, R.C., Conaway, J.W. J. Biol. Chem. (2005)
- Pertussis toxin-sensitive G proteins as mediators of the signal transduction pathways activated by cytomegalovirus infection of smooth muscle cells. Shibutani, T., Johnson, T.M., Yu, Z.X., Ferrans, V.J., Moss, J., Epstein, S.E. J. Clin. Invest. (1997)
- Boswellic acids stimulate arachidonic acid release and 12-lipoxygenase activity in human platelets independent of Ca2+ and differentially interact with platelet-type 12-lipoxygenase. Poeckel, D., Tausch, L., Kather, N., Jauch, J., Werz, O. Mol. Pharmacol. (2006)
- Potentiation by vitamin D analogs of TNFalpha and ceramide-induced apoptosis in MCF-7 cells is associated with activation of cytosolic phospholipase A2. Pirianov, G., Danielsson, C., Carlberg, C., James, S.Y., Colston, K.W. Cell Death Differ. (1999)
- 1,25-Dihydroxyvitamin D3 protects human leukemic cells from tumor necrosis factor-induced apoptosis via inactivation of cytosolic phospholipase A2. Wu, Y.L., Jiang, X.R., Lillington, D.M., Allen, P.D., Newland, A.C., Kelsey, S.M. Cancer Res. (1998)
- Tip60 is regulated by circadian transcription factor clock and is involved in cisplatin resistance. Miyamoto, N., Izumi, H., Noguchi, T., Nakajima, Y., Ohmiya, Y., Shiota, M., Kidani, A., Tawara, A., Kohno, K. J. Biol. Chem. (2008)
- A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM. Sun, Y., Jiang, X., Chen, S., Fernandes, N., Price, B.D. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Tip60 interacts with human interleukin-9 receptor alpha-chain. Sliva, D., Zhu, Y.X., Tsai, S., Kamine, J., Yang, Y.C. Biochem. Biophys. Res. Commun. (1999)
- The APP intracellular domain forms nuclear multiprotein complexes and regulates the transcription of its own precursor. von Rotz, R.C., Kohli, B.M., Bosset, J., Meier, M., Suzuki, T., Nitsch, R.M., Konietzko, U. J. Cell. Sci. (2004)
- p14ARF promotes RB accumulation through inhibition of its Tip60-dependent acetylation. Leduc, C., Claverie, P., Eymin, B., Col, E., Khochbin, S., Brambilla, E., Gazzeri, S. Oncogene (2006)
- PML3 Orchestrates the Nuclear Dynamics and Function of TIP60. Wu, Q., Hu, H., Lan, J., Emenari, C., Wang, Z., Chang, K.S., Huang, H., Yao, X. J. Biol. Chem. (2009)
- Tip60 is a co-repressor for STAT3. Xiao, H., Chung, J., Kao, H.Y., Yang, Y.C. J. Biol. Chem. (2003)
- The gamma secretase-generated carboxyl-terminal domain of the amyloid precursor protein induces apoptosis via Tip60 in H4 cells. Kinoshita, A., Whelan, C.M., Berezovska, O., Hyman, B.T. J. Biol. Chem. (2002)
- Tip60 inhibits activation of CREB protein by protein kinase A. Gavaravarapu, S., Kamine, J. Biochem. Biophys. Res. Commun. (2000)
- Regulation of TIP60 by ATF2 modulates ATM activation. Bhoumik, A., Singha, N., O'Connell, M.J., Ronai, Z.A. J. Biol. Chem. (2008)
- TIP60 represses transcriptional activity of p73beta via an MDM2-bridged ternary complex. Kim, J.W., Song, P.I., Jeong, M.H., An, J.H., Lee, S.Y., Jang, S.M., Song, K.H., Armstrong, C.A., Choi, K.H. J. Biol. Chem. (2008)
- The c-MYC oncoprotein is a substrate of the acetyltransferases hGCN5/PCAF and TIP60. Patel, J.H., Du, Y., Ard, P.G., Phillips, C., Carella, B., Chen, C.J., Rakowski, C., Chatterjee, C., Lieberman, P.M., Lane, W.S., Blobel, G.A., McMahon, S.B. Mol. Cell. Biol. (2004)
- E2F-dependent histone acetylation and recruitment of the Tip60 acetyltransferase complex to chromatin in late G1. Taubert, S., Gorrini, C., Frank, S.R., Parisi, T., Fuchs, M., Chan, H.M., Livingston, D.M., Amati, B. Mol. Cell. Biol. (2004)
- Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans. Doyon, Y., Selleck, W., Lane, W.S., Tan, S., Côté, J. Mol. Cell. Biol. (2004)
- Transcription regulation by the adaptor protein Fe65 and the nucleosome assembly factor SET. Telese, F., Bruni, P., Donizetti, A., Gianni, D., D'Ambrosio, C., Scaloni, A., Zambrano, N., Rosenfeld, M.G., Russo, T. EMBO Rep. (2005)
- Unique targeting of cytosolic phospholipase A2 to plasma membranes mediated by the NADPH oxidase in phagocytes. Shmelzer, Z., Haddad, N., Admon, E., Pessach, I., Leto, T.L., Eitan-Hazan, Z., Hershfinkel, M., Levy, R. J. Cell Biol. (2003)
- Failure to activate cytosolic phospholipase A2 causes TNF resistance in human leukemic cells. Wu, Y.L., Jiang, X.R., Newland, A.C., Kelsey, S.M. J. Immunol. (1998)