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Gene Review:

Proc-R - Proctolin receptor

Drosophila melanogaster

Synonyms: CG6986, Dmel\CG6986, Proc R, ProcR, anon-WO0170980.73, ...

Johnson, E.C. et al., Egerod, K. et al.

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High impact information on CG6986

In competition-based studies, the CG6986 receptor binds proctolin with high affinity (IC(50) = 4 nM) [1].
By microarray analysis, CG6986 transcript is consistently detected in head mRNA of different genotypes, and under different environmental conditions [1].
The website of the Drosophila Genome Project (www.flybase.org) contains the sequence of an annotated gene CG6986, which is predicted to code for a G protein-coupled receptor [2].

Biological context of CG6986

When expressed in mammalian cells, CG6986 confers second messenger activation after proctolin application, with an EC(50) of 0.3 nM [1].

References

Identification and characterization of a G protein-coupled receptor for the neuropeptide proctolin in Drosophilamelanogaster. Johnson, E.C., Garczynski, S.F., Park, D., Crim, J.W., Nassel, D.R., Taghert, P.H. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
Molecular identification of the first insect proctolin receptor. Egerod, K., Reynisson, E., Hauser, F., Williamson, M., Cazzamali, G., Grimmelikhuijzen, C.J. Biochem. Biophys. Res. Commun. (2003) [Pubmed]

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