Disease relevance of Tre1

• A TA receptor cDNA encoding a putative seven transmembrane domain G-protein coupled receptor was amplified from Drosophila melanogaster head cDNA phage library [1].

Psychiatry related information on Tre1

• Together these findings may unlock the solution to a problem that has plagued the molecular study of olfaction since the cloning of the first olfactory G protein-coupled receptor over twelve years ago [2].

High impact information on Tre1

• Pleiotropic fitness effects of the Tre1-Gr5a region in Drosophila melanogaster [3].
• Our study demonstrates the importance of morphogenetic regulation in blood-brain barrier development and places GPCR signaling at its core [4].
• Arrestin binding determines the rate of inactivation of the G protein-coupled receptor rhodopsin in vivo [5].
• In this paper, we develop a theory that describes the kinetics of inactivation of the G protein-coupled receptor rhodopsin based on the rate of arrestin binding and test the theory using a combination of genetic and electrophysiological techniques in Drosophila photoreceptors [5].
• Overexpression of the Tre1 gene restored the taste sensitivity to trehalose in the Tre1 deletion mutant [6].

Biological context of Tre1

• A total of three polymorphic sites leading to amino acid changes in CG3171 were not correlated with the gustatory phenotype [7].
• We recently identified from the Drosophila genome database a large family of G protein-coupled receptor genes, the Gr genes, and predicted that they encode taste receptors on the basis of their structure and specificity of expression [8].
• Maternal and zygotic expression of scattershot is required, but the migration and cell death functions can be genetically uncoupled [9].
• Here we show that the putative G protein-coupled receptor Methuselah (Mth) is required in the presynaptic motor neuron to acutely upregulate neurotransmitter exocytosis at larval Drosophila NMJs [10].
• Recently, termination of the active state of two such receptors, the beta-adrenergic receptor and rhodopsin, has been shown to be mediated by agonist- or light-dependent phosphorylation of the receptor by members of a family of protein-serine/threonine kinases (here referred to as G protein-coupled receptor kinases) [11].

Anatomical context of Tre1

• We propose that Tre1 acts in a manner similar to chemokine receptors required during transepithelial migration of leukocytes, implying an evolutionarily conserved mechanism of transepithelial migration [12].
• In tre1 mutant embryos, most germ cells do not exit the PMG [12].
• The scattershot gene is defined by a mutation that disrupts both germ cell migration and the death of germ cells ectopic to the gonad [9].
• The formation of normal dendritic fields and the competition between dendrites of homologous neurons require the proper expression level of Flamingo, a G protein-coupled receptor-like protein, in embryonic neurons [13].
• In sensory neurons, cardiac muscle and other tissues, G protein-coupled receptors are desensitized through phosphorylation by a family of kinases, the G protein-coupled receptor kinases (GRKs) [14].

Associations of Tre1 with chemical compounds

• These results provide direct evidence that Tre1 encodes a putative taste receptor for trehalose in Drosophila [6].
• Identification and characterization of a G protein-coupled receptor for the neuropeptide proctolin in Drosophilamelanogaster [15].
• Bursicon, the insect cuticle-hardening hormone, is a heterodimeric cystine knot protein that activates G protein-coupled receptor LGR2 [16].
• This was supported by evidence that wing cell death was inhibited by a mutation of rickets, which encodes a G-protein coupled receptor in the glycoprotein hormone family that is a putative bursicon receptor [17].
• Molecular cloning, genomic organization, developmental regulation, and a knock-out mutant of a novel leu-rich repeats-containing G protein-coupled receptor (DLGR-2) from Drosophila melanogaster [18].

Other interactions of Tre1

• One (CG3171) encodes a rhodopsin family G protein receptor [3, 4], and the other (Gr5a) is a member of a chemosensory gene family encoding a putative gustatory receptor [5-7] [7].
• Arrestin function in inactivation of G protein-coupled receptor rhodopsin in vivo [19].
• The database from the Drosophila Genome Project contains a gene, CG9918, annotated to code for a G protein-coupled receptor [20].
• The website of the Drosophila Genome Project (www.flybase.org) contains the sequence of an annotated gene CG6986, which is predicted to code for a G protein-coupled receptor [21].
• A G protein-coupled receptor phosphatase required for rhodopsin function [22].

References