The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Tre1  -  Trapped in endoderm 1

Drosophila melanogaster

Synonyms: BEST:LD12308, CG3171, Dmel\CG3171, LD12308, Protein trapped in endoderm-1, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Tre1


Psychiatry related information on Tre1

  • Together these findings may unlock the solution to a problem that has plagued the molecular study of olfaction since the cloning of the first olfactory G protein-coupled receptor over twelve years ago [2].

High impact information on Tre1


Biological context of Tre1

  • A total of three polymorphic sites leading to amino acid changes in CG3171 were not correlated with the gustatory phenotype [7].
  • We recently identified from the Drosophila genome database a large family of G protein-coupled receptor genes, the Gr genes, and predicted that they encode taste receptors on the basis of their structure and specificity of expression [8].
  • Maternal and zygotic expression of scattershot is required, but the migration and cell death functions can be genetically uncoupled [9].
  • Here we show that the putative G protein-coupled receptor Methuselah (Mth) is required in the presynaptic motor neuron to acutely upregulate neurotransmitter exocytosis at larval Drosophila NMJs [10].
  • Recently, termination of the active state of two such receptors, the beta-adrenergic receptor and rhodopsin, has been shown to be mediated by agonist- or light-dependent phosphorylation of the receptor by members of a family of protein-serine/threonine kinases (here referred to as G protein-coupled receptor kinases) [11].

Anatomical context of Tre1


Associations of Tre1 with chemical compounds


Other interactions of Tre1


  1. Molecular response of Drosophila melanogaster tyramine receptor cascade to plant essential oils. Enan, E.E. Insect Biochem. Mol. Biol. (2005) [Pubmed]
  2. Olfactory Receptor Localization and Function: An Emerging Role for GPCR Heterodimerization. Hague, C., Hall, R.A., Minneman, K.P. Molecular interventions. (2004) [Pubmed]
  3. Pleiotropic fitness effects of the Tre1-Gr5a region in Drosophila melanogaster. Rollmann, S.M., Magwire, M.M., Morgan, T.J., Ozsoy, E.D., Yamamoto, A., Mackay, T.F., Anholt, R.R. Nat. Genet. (2006) [Pubmed]
  4. GPCR signaling is required for blood-brain barrier formation in drosophila. Schwabe, T., Bainton, R.J., Fetter, R.D., Heberlein, U., Gaul, U. Cell (2005) [Pubmed]
  5. Arrestin binding determines the rate of inactivation of the G protein-coupled receptor rhodopsin in vivo. Ranganathan, R., Stevens, C.F. Cell (1995) [Pubmed]
  6. Molecular identification of a taste receptor gene for trehalose in Drosophila. Ishimoto, H., Matsumoto, A., Tanimura, T. Science (2000) [Pubmed]
  7. Trehalose sensitivity in Drosophila correlates with mutations in and expression of the gustatory receptor gene Gr5a. Ueno, K., Ohta, M., Morita, H., Mikuni, Y., Nakajima, S., Yamamoto, K., Isono, K. Curr. Biol. (2001) [Pubmed]
  8. A Gr receptor is required for response to the sugar trehalose in taste neurons of Drosophila. Dahanukar, A., Foster, K., van der Goes van Naters, W.M., Carlson, J.R. Nat. Neurosci. (2001) [Pubmed]
  9. Identification of X-linked genes required for migration and programmed cell death of Drosophila melanogaster germ cells. Coffman, C.R., Strohm, R.C., Oakley, F.D., Yamada, Y., Przychodzin, D., Boswell, R.E. Genetics (2002) [Pubmed]
  10. Presynaptic regulation of neurotransmission in Drosophila by the g protein-coupled receptor methuselah. Song, W., Ranjan, R., Dawson-Scully, K., Bronk, P., Marin, L., Seroude, L., Lin, Y.J., Nie, Z., Atwood, H.L., Benzer, S., Zinsmaier, K.E. Neuron (2002) [Pubmed]
  11. Isolation of Drosophila genes encoding G protein-coupled receptor kinases. Cassill, J.A., Whitney, M., Joazeiro, C.A., Becker, A., Zuker, C.S. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  12. Tre1, a G protein-coupled receptor, directs transepithelial migration of Drosophila germ cells. Kunwar, P.S., Starz-Gaiano, M., Bainton, R.J., Heberlein, U., Lehmann, R. PLoS Biol. (2003) [Pubmed]
  13. Control of dendritic field formation in Drosophila: the roles of flamingo and competition between homologous neurons. Gao, F.B., Kohwi, M., Brenman, J.E., Jan, L.Y., Jan, Y.N. Neuron (2000) [Pubmed]
  14. The Drosophila G-protein-coupled receptor kinase homologue Gprk2 is required for egg morphogenesis. Schneider, L.E., Spradling, A.C. Development (1997) [Pubmed]
  15. Identification and characterization of a G protein-coupled receptor for the neuropeptide proctolin in Drosophilamelanogaster. Johnson, E.C., Garczynski, S.F., Park, D., Crim, J.W., Nassel, D.R., Taghert, P.H. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  16. Bursicon, the insect cuticle-hardening hormone, is a heterodimeric cystine knot protein that activates G protein-coupled receptor LGR2. Luo, C.W., Dewey, E.M., Sudo, S., Ewer, J., Hsu, S.Y., Honegger, H.W., Hsueh, A.J. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  17. Activation of the cAMP/PKA signaling pathway is required for post-ecdysial cell death in wing epidermal cells of Drosophila melanogaster. Kimura, K., Kodama, A., Hayasaka, Y., Ohta, T. Development (2004) [Pubmed]
  18. Molecular cloning, genomic organization, developmental regulation, and a knock-out mutant of a novel leu-rich repeats-containing G protein-coupled receptor (DLGR-2) from Drosophila melanogaster. Eriksen, K.K., Hauser, F., Schiøtt, M., Pedersen, K.M., Søndergaard, L., Grimmelikhuijzen, C.J. Genome Res. (2000) [Pubmed]
  19. Arrestin function in inactivation of G protein-coupled receptor rhodopsin in vivo. Dolph, P.J., Ranganathan, R., Colley, N.J., Hardy, R.W., Socolich, M., Zuker, C.S. Science (1993) [Pubmed]
  20. The Drosophila gene CG9918 codes for a pyrokinin-1 receptor. Cazzamali, G., Torp, M., Hauser, F., Williamson, M., Grimmelikhuijzen, C.J. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  21. Molecular identification of the first insect proctolin receptor. Egerod, K., Reynisson, E., Hauser, F., Williamson, M., Cazzamali, G., Grimmelikhuijzen, C.J. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  22. A G protein-coupled receptor phosphatase required for rhodopsin function. Vinós, J., Jalink, K., Hardy, R.W., Britt, S.G., Zuker, C.S. Science (1997) [Pubmed]
WikiGenes - Universities