The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

HLCS  -  holocarboxylase synthetase (biotin...

Homo sapiens

Synonyms: Biotin apo-protein ligase, Biotin--protein ligase, HCS
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of HLCS


Psychiatry related information on HLCS

  • Each patient completed standard self-administered psychologic tests to evaluate mood disturbance (Profile of Mood States [POMS]) and responsibility taken for overall health care (Health Locus of Control [HLCS]) [4].

High impact information on HLCS

  • BPL catalyzes the covalent attachment of a single biotin to the fusion protein in vivo [5].
  • A plasmid encoding both a biotin acceptor peptide-GLuc fusion protein as well as the enzyme biotin protein ligase (BPL) is engineered by using GLuc cDNA as a starting template [5].
  • Enzymatic attachment of biotin to proteins requires the interaction of a distinct domain of the acceptor protein (the "biotin domain") with the enzyme, biotin protein ligase, that catalyzes this essential and rare post-translational modification [6].
  • The unusual and insufficient response of this patient to biotin treatment can be explained by the effect of the combination of the common HLCS allele IVS10 +5 g>a on one chromosome and a truncating mutation on the other [7].
  • The different phenotypes (early and late presenting) may be related to a spectrum of mutations in HLCS gene [1].


  1. A genomic approach to mutation analysis of holocarboxylase synthetase gene in three Chinese patients with late-onset holocarboxylase synthetase deficiency. Tang, N.L., Hui, J., Yong, C.K., Wong, L.T., Applegarth, D.A., Vallance, H.D., Law, L.K., Fung, S.L., Mak, T.W., Sung, Y.M., Cheung, K.L., Fok, T.F. Clin. Biochem. (2003) [Pubmed]
  2. Nonenzymatic biotinylation of a biotin carboxyl carrier protein: unusual reactivity of the physiological target lysine. Streaker, E.D., Beckett, D. Protein Sci. (2006) [Pubmed]
  3. Computational identification of BioR, a transcriptional regulator of biotin metabolism in Alphaproteobacteria, and of its binding signal. Rodionov, D.A., Gelfand, M.S. FEMS Microbiol. Lett. (2006) [Pubmed]
  4. Psychological distress among women with breast problems. Romsaas, E.P., Malec, J.F., Javenkoski, B.R., Trump, D.L., Wolberg, W.H. Cancer (1986) [Pubmed]
  5. Recombinant Gaussia luciferase. Overexpression, purification, and analytical application of a bioluminescent reporter for DNA hybridization. Verhaegent, M., Christopoulos, T.K. Anal. Chem. (2002) [Pubmed]
  6. Molecular biology of biotin attachment to proteins. Chapman-Smith, A., Cronan, J.E. J. Nutr. (1999) [Pubmed]
  7. Partial response to biotin therapy in a patient with holocarboxylase synthetase deficiency: clinical, biochemical, and molecular genetic aspects. Santer, R., Muhle, H., Suormala, T., Baumgartner, E.R., Duran, M., Yang, X., Aoki, Y., Suzuki, Y., Stephani, U. Mol. Genet. Metab. (2003) [Pubmed]
WikiGenes - Universities