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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Zhx2  -  zinc fingers and homeoboxes 2

Rattus norvegicus

Synonyms: AFP regulator 1, Afr1, Alpha-fetoprotein regulator 1, Raf, Regulator of AFP, ...
 
 
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High impact information on Zhx2

  • Finally, RKIP depletion or Raf hyperactivation reduces kinetochore localization and kinase activity of Aurora B, a regulator of the spindle checkpoint [1].
  • To examine whether Hsp90N could therefore substitute for Ras in Raf recruitment to the cell membrane, Hsp90N was transfected in c-Ras-deficient, 10T1/2-derived preadipocytes [2].
  • Our results indicate that, as shown before for activated Ras or Raf, the introduction of even low levels of Hsp90N through transfection in c-Ras-deficient preadipocytes causes a dramatic block of differentiation [2].
  • Hsp90N was found to activate Raf in transiently transfected cells, while Rat F111 fibroblasts stably transfected with Hsp90N exhibited elevated activity of the Raf and downstream ERK kinases [2].

References

  1. Raf kinase inhibitory protein regulates aurora B kinase and the spindle checkpoint. Eves, E.M., Shapiro, P., Naik, K., Klein, U.R., Trakul, N., Rosner, M.R. Mol. Cell (2006) [Pubmed]
  2. The role of Hsp90N, a new member of the Hsp90 family, in signal transduction and neoplastic transformation. Grammatikakis, N., Vultur, A., Ramana, C.V., Siganou, A., Schweinfest, C.W., Watson, D.K., Raptis, L. J. Biol. Chem. (2002) [Pubmed]
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