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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Kinetochores


Psychiatry related information on Kinetochores


High impact information on Kinetochores

  • Here, we show that CLASP1, a microtubule-associated protein, localizes preferentially near the plus ends of growing spindle microtubules and is also a component of a kinetochore region that we term the outer corona [7].
  • One of the most intriguing aspects of mitosis is the ability of kinetochores to hold onto plus ends of microtubules that are actively gaining or losing tubulin subunits [7].
  • Kinetochores detach from old SPBs and reattach to old and new SPBs with equal frequency in IPL1+ cells, but remain attached to old SPBs in ipl1 mutants [8].
  • This raises the possibility that Ipl1-Sli15 facilitates bi-orientation by promoting turnover of kinetochore-SPB connections until traction of sister kinetochores toward opposite spindle poles creates tension in the surrounding chromatin [8].
  • By deleting genes that are upregulated during meiosis, we identified in Saccharomyces cerevisiae a kinetochore associated protein, Mam1 (Monopolin), which is essential for monopolar attachment [9].

Biological context of Kinetochores


Anatomical context of Kinetochores


Associations of Kinetochores with chemical compounds


Gene context of Kinetochores

  • In S. cerevisiae, the four-protein Cbf3 complex binds to the essential CDEIII region of centromeric DNA to initiate kinetochore assembly [13].
  • Together, the genetic and biochemical data indicate that CTF13 is an essential kinetochore protein [14].
  • Kinetochore localization of murine Bub1 is required for normal mitotic timing and checkpoint response to spindle damage [11].
  • Ask1 localizes along mitotic spindles and to kinetochores, and cross-links to centromeric DNA [24].
  • In addition, Ctf3p, Mcm22p, and Mcm16p have a localization pattern similar to other kinetochore proteins [25].

Analytical, diagnostic and therapeutic context of Kinetochores


  1. Specific destruction of kinetochore protein CENP-C and disruption of cell division by herpes simplex virus immediate-early protein Vmw110. Everett, R.D., Earnshaw, W.C., Findlay, J., Lomonte, P. EMBO J. (1999) [Pubmed]
  2. Human survivin is a kinetochore-associated passenger protein. Skoufias, D.A., Mollinari, C., Lacroix, F.B., Margolis, R.L. J. Cell Biol. (2000) [Pubmed]
  3. A 47-kDa human nuclear protein recognized by antikinetochore autoimmune sera is homologous with the protein encoded by RCC1, a gene implicated in onset of chromosome condensation. Bischoff, F.R., Maier, G., Tilz, G., Ponstingl, H. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  4. Characterisation of centromere (kinetochore) antigen reactive with sera of patients with a scleroderma variant (CREST syndrome). Nishikai, M., Okano, Y., Yamashita, H., Watanabe, M. Ann. Rheum. Dis. (1984) [Pubmed]
  5. Localization of Ca(2+)-calmodulin to the kinetochore of C6 glioma cells: an investigation of the anti-tumour effects of calmodulin antagonists in the treatment of brain tumours. Mitsuyama, F., Kanno, T. Neurol. Res. (1993) [Pubmed]
  6. Distinct mechanisms govern the localisation of Drosophila CLIP-190 to unattached kinetochores and microtubule plus-ends. Dzhindzhev, N.S., Rogers, S.L., Vale, R.D., Ohkura, H. J. Cell. Sci. (2005) [Pubmed]
  7. Human CLASP1 is an outer kinetochore component that regulates spindle microtubule dynamics. Maiato, H., Fairley, E.A., Rieder, C.L., Swedlow, J.R., Sunkel, C.E., Earnshaw, W.C. Cell (2003) [Pubmed]
  8. Evidence that the Ipl1-Sli15 (Aurora kinase-INCENP) complex promotes chromosome bi-orientation by altering kinetochore-spindle pole connections. Tanaka, T.U., Rachidi, N., Janke, C., Pereira, G., Galova, M., Schiebel, E., Stark, M.J., Nasmyth, K. Cell (2002) [Pubmed]
  9. Functional genomics identifies monopolin: a kinetochore protein required for segregation of homologs during meiosis i. Tóth, A., Rabitsch, K.P., Gálová, M., Schleiffer, A., Buonomo, S.B., Nasmyth, K. Cell (2000) [Pubmed]
  10. CENP-E is a plus end-directed kinetochore motor required for metaphase chromosome alignment. Wood, K.W., Sakowicz, R., Goldstein, L.S., Cleveland, D.W. Cell (1997) [Pubmed]
  11. Kinetochore localization of murine Bub1 is required for normal mitotic timing and checkpoint response to spindle damage. Taylor, S.S., McKeon, F. Cell (1997) [Pubmed]
  12. Budding yeast SKP1 encodes an evolutionarily conserved kinetochore protein required for cell cycle progression. Connelly, C., Hieter, P. Cell (1996) [Pubmed]
  13. Regulating the yeast kinetochore by ubiquitin-dependent degradation and Skp1p-mediated phosphorylation. Kaplan, K.B., Hyman, A.A., Sorger, P.K. Cell (1997) [Pubmed]
  14. Identification of essential components of the S. cerevisiae kinetochore. Doheny, K.F., Sorger, P.K., Hyman, A.A., Tugendreich, S., Spencer, F., Hieter, P. Cell (1993) [Pubmed]
  15. The anaphase promoting complex/cyclosome is recruited to centromeres by the spindle assembly checkpoint. Acquaviva, C., Herzog, F., Kraft, C., Pines, J. Nat. Cell Biol. (2004) [Pubmed]
  16. Rapid microtubule-independent dynamics of Cdc20 at kinetochores and centrosomes in mammalian cells. Kallio, M.J., Beardmore, V.A., Weinstein, J., Gorbsky, G.J. J. Cell Biol. (2002) [Pubmed]
  17. Characterization of the kinetochore binding domain of CENP-E reveals interactions with the kinetochore proteins CENP-F and hBUBR1. Chan, G.K., Schaar, B.T., Yen, T.J. J. Cell Biol. (1998) [Pubmed]
  18. Nup358 integrates nuclear envelope breakdown with kinetochore assembly. Salina, D., Enarson, P., Rattner, J.B., Burke, B. J. Cell Biol. (2003) [Pubmed]
  19. Association of spindle assembly checkpoint component XMAD2 with unattached kinetochores. Chen, R.H., Waters, J.C., Salmon, E.D., Murray, A.W. Science (1996) [Pubmed]
  20. Crm1 is a mitotic effector of Ran-GTP in somatic cells. Arnaoutov, A., Azuma, Y., Ribbeck, K., Joseph, J., Boyarchuk, Y., Karpova, T., McNally, J., Dasso, M. Nat. Cell Biol. (2005) [Pubmed]
  21. On the mechanism of anaphase A: evidence that ATP is needed for microtubule disassembly and not generation of polewards force. Spurck, T.P., Pickett-Heaps, J.D. J. Cell Biol. (1987) [Pubmed]
  22. Ribonucleoprotein staining of centrioles and kinetochores in newt lung cell spindles. Rieder, C.L. J. Cell Biol. (1979) [Pubmed]
  23. Fractionation and initial characterization of the kinetochore from mammalian metaphase chromosomes. Valdivia, M.M., Brinkley, B.R. J. Cell Biol. (1985) [Pubmed]
  24. The mitotic spindle is required for loading of the DASH complex onto the kinetochore. Li, Y., Bachant, J., Alcasabas, A.A., Wang, Y., Qin, J., Elledge, S.J. Genes Dev. (2002) [Pubmed]
  25. Ctf3p, the Mis6 budding yeast homolog, interacts with Mcm22p and Mcm16p at the yeast outer kinetochore. Measday, V., Hailey, D.W., Pot, I., Givan, S.A., Hyland, K.M., Cagney, G., Fields, S., Davis, T.N., Hieter, P. Genes Dev. (2002) [Pubmed]
  26. Molecular characterization of the 50-kD subunit of dynactin reveals function for the complex in chromosome alignment and spindle organization during mitosis. Echeverri, C.J., Paschal, B.M., Vaughan, K.T., Vallee, R.B. J. Cell Biol. (1996) [Pubmed]
  27. CENP-C is required for maintaining proper kinetochore size and for a timely transition to anaphase. Tomkiel, J., Cooke, C.A., Saitoh, H., Bernat, R.L., Earnshaw, W.C. J. Cell Biol. (1994) [Pubmed]
  28. Centromere protein B assembles human centromeric alpha-satellite DNA at the 17-bp sequence, CENP-B box. Muro, Y., Masumoto, H., Yoda, K., Nozaki, N., Ohashi, M., Okazaki, T. J. Cell Biol. (1992) [Pubmed]
  29. Probing the Saccharomyces cerevisiae centromeric DNA (CEN DNA)-binding factor 3 (CBF3) kinetochore complex by using atomic force microscopy. Pietrasanta, L.I., Thrower, D., Hsieh, W., Rao, S., Stemmann, O., Lechner, J., Carbon, J., Hansma, H. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  30. Hec1 and nuf2 are core components of the kinetochore outer plate essential for organizing microtubule attachment sites. DeLuca, J.G., Dong, Y., Hergert, P., Strauss, J., Hickey, J.M., Salmon, E.D., McEwen, B.F. Mol. Biol. Cell (2005) [Pubmed]
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