High impact information on pod1

• Taken together, these results reveal novel activities for pod-1 and show that proper levels of Dpod1, an actin/MT crosslinker, must be maintained in the growth cone for correct axon guidance [1].
• Drosophila pod-1 crosslinks both actin and microtubules and controls the targeting of axons [1].
• In cultured S2 cells, Dpod1 colocalizes with lamellar actin and MTs, and overexpression remodels the cytoskeleton to promote dynamic neurite-like actin-dependent projections [1].

Anatomical context of pod1

• In either the absence or overabundance of Dpod1, growth cone targeting but not outgrowth is disrupted [1].

References