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Gene Review

pod1  -  CG4532 gene product from transcript CG4532-RG

Drosophila melanogaster

Synonyms: BEST:LD37601, BcDNA:LD08951, CG4532, Dmel\CG4532, Dpod1, ...
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High impact information on pod1

  • Taken together, these results reveal novel activities for pod-1 and show that proper levels of Dpod1, an actin/MT crosslinker, must be maintained in the growth cone for correct axon guidance [1].
  • Drosophila pod-1 crosslinks both actin and microtubules and controls the targeting of axons [1].
  • In cultured S2 cells, Dpod1 colocalizes with lamellar actin and MTs, and overexpression remodels the cytoskeleton to promote dynamic neurite-like actin-dependent projections [1].

Anatomical context of pod1

  • In either the absence or overabundance of Dpod1, growth cone targeting but not outgrowth is disrupted [1].


  1. Drosophila pod-1 crosslinks both actin and microtubules and controls the targeting of axons. Rothenberg, M.E., Rogers, S.L., Vale, R.D., Jan, L.Y., Jan, Y.N. Neuron (2003) [Pubmed]
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