Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

HMX1 - H6 family homeobox 1

Homo sapiens

Synonyms: H6, Homeobox protein H6, Homeobox protein HMX1, NKX5-3

Amendt, B.A. et al., Yoshiura, K. et al., Campbell, E.M. et al.

Amendt, Sutherland, Russo,

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High impact information on HMX1

Transcriptional antagonism between Hmx1 and Nkx2.5 for a shared DNA-binding site [1].
Unexpectedly, the human Hmx1 protein specifically repressed transcription from a luciferase reporter gene containing 3 copies of the 5'-CAAGTG-3' sequence [1].
We previously isolated the human HMX1 (H6) gene, a novel homeobox-containing gene of the HMX family, from a human embryonic craniofacial cDNA library [2].
Two genes were assigned since they were present in clones that contained mapped markers (HGFAC and HMX1) [3].

References

Transcriptional antagonism between Hmx1 and Nkx2.5 for a shared DNA-binding site. Amendt, B.A., Sutherland, L.B., Russo, A.F. J. Biol. Chem. (1999) [Pubmed]
Cloning, characterization, and mapping of the mouse homeobox gene Hmx1. Yoshiura, K., Leysens, N.J., Reiter, R.S., Murray, J.C. Genomics (1998) [Pubmed]
Fine mapping a quantitative trait locus affecting ovulation rate in swine on chromosome 8. Campbell, E.M., Nonneman, D., Rohrer, G.A. J. Anim. Sci. (2003) [Pubmed]

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