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Gene Review

HMX1  -  H6 family homeobox 1

Homo sapiens

Synonyms: H6, Homeobox protein H6, Homeobox protein HMX1, NKX5-3
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High impact information on HMX1

  • Transcriptional antagonism between Hmx1 and Nkx2.5 for a shared DNA-binding site [1].
  • Unexpectedly, the human Hmx1 protein specifically repressed transcription from a luciferase reporter gene containing 3 copies of the 5'-CAAGTG-3' sequence [1].
  • We previously isolated the human HMX1 (H6) gene, a novel homeobox-containing gene of the HMX family, from a human embryonic craniofacial cDNA library [2].
  • Two genes were assigned since they were present in clones that contained mapped markers (HGFAC and HMX1) [3].


  1. Transcriptional antagonism between Hmx1 and Nkx2.5 for a shared DNA-binding site. Amendt, B.A., Sutherland, L.B., Russo, A.F. J. Biol. Chem. (1999) [Pubmed]
  2. Cloning, characterization, and mapping of the mouse homeobox gene Hmx1. Yoshiura, K., Leysens, N.J., Reiter, R.S., Murray, J.C. Genomics (1998) [Pubmed]
  3. Fine mapping a quantitative trait locus affecting ovulation rate in swine on chromosome 8. Campbell, E.M., Nonneman, D., Rohrer, G.A. J. Anim. Sci. (2003) [Pubmed]
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