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Gene Review

HNRNPA2B1  -  heterogeneous nuclear ribonucleoprotein A2/B1

Homo sapiens

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Disease relevance of HNRPA2B1

  • This imprinted domain arose after a region bearing UBE3A (Angelman syndrome) fused with an unlinked region bearing SNRPN (Prader-Willi syndrome), which had duplicated from the non-imprinted SNRPB/B'. This region independently acquired several retroposed gene copies and arrays of small nucleolar RNAs from different parts of the genome [1].

High impact information on HNRPA2B1


  1. Recent assembly of an imprinted domain from non-imprinted components. Rapkins, R.W., Hore, T., Smithwick, M., Ager, E., Pask, A.J., Renfree, M.B., Kohn, M., Hameister, H., Nicholls, R.D., Deakin, J.E., Graves, J.A. PLoS Genet. (2006) [Pubmed]
  2. Transgenes encompassing dual-promoter CpG islands from the human TBP and HNRPA2B1 loci are resistant to heterochromatin-mediated silencing. Antoniou, M., Harland, L., Mustoe, T., Williams, S., Holdstock, J., Yague, E., Mulcahy, T., Griffiths, M., Edwards, S., Ioannou, P.A., Mountain, A., Crombie, R. Genomics (2003) [Pubmed]
  3. Structure and expression of the gene (HNRPA2B1) encoding the human hnRNP protein A2/B1. Kozu, T., Henrich, B., Schäfer, K.P. Genomics (1995) [Pubmed]
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