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Gene Review

Nceh1  -  neutral cholesterol ester hydrolase 1

Mus musculus

Synonyms: Aadacl1, Arylacetamide deacetylase-like 1, B230106I24Rik, CPO-BP, Chlorpyrifos oxon-binding protein, ...
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High impact information on Aadacl1

  • Therefore, it was surprising that the predominant mouse brain protein labeled in vitro by [(3)H-ethyl]CPO (1 nM) (designated CPO-binding protein or CPO-BP) is not one of these known OP toxicant targets [1].
  • Using three chemical labeling reagents, i.e., [(3)H]CPO and the activity-based proteomic probes fluorophosphonate-biotin and fluorophosphonate-rhodamine, mouse brain CPO-BP is identified as serine hydrolase KIAA1363 of unknown function [1].


  1. A brain detoxifying enzyme for organophosphorus nerve poisons. Nomura, D.K., Leung, D., Chiang, K.P., Quistad, G.B., Cravatt, B.F., Casida, J.E. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
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