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Chemical Compound Review

Dursbanoxon     2,3,5-trichloro-6- diethoxyphosphoryloxy...

Synonyms: CHEMBL444970, CCRIS 7774, CHEBI:554435, DNC014028, LS-107747, ...
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Disease relevance of CCRIS 7774


High impact information on CCRIS 7774


Biological context of CCRIS 7774


Anatomical context of CCRIS 7774


Associations of CCRIS 7774 with other chemical compounds


Gene context of CCRIS 7774


Analytical, diagnostic and therapeutic context of CCRIS 7774

  • Previous studies had indicated that the levels of serum PON1 in gene therapy with adenoviral vector could decrease the toxicity of CPO [24].
  • Following single-pass perfusion of mouse livers in situ with the organophosphate pesticide chlorpyrifos, the cholinesterase inhibitor chlorpyrifos oxon could not be detected in effluent perfusate [25].
  • Strains (BESS and BKRR) homogeneous for each variant were isolated and their relative susceptibilities to methomyl, chlorpyrifos, and chlorpyrifos-oxon assessed by topical application bioassay [26].
  • The effect of CPF and CPO on gene expression in Caco-2 cells was tested as a function of time using RT-PCR and competitive PCR (compPCR) techniques [27].
  • Determination of the analytes in spiked river water samples by use of the dmAChE biosensor resulted in recoveries from 50 to 90 % for chlorpyrifos oxon at levels of 20 to 40 nmol L(-1), 50 to 100 % for paraoxon at 0.6 to 0.8 micro mol L(-1), and 140 to 190 % for malaoxon at 0.6 to 1.2 micro mol L(-1) [28].


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  2. Mice lacking serum paraoxonase are susceptible to organophosphate toxicity and atherosclerosis. Shih, D.M., Gu, L., Xia, Y.R., Navab, M., Li, W.F., Hama, S., Castellani, L.W., Furlong, C.E., Costa, L.G., Fogelman, A.M., Lusis, A.J. Nature (1998) [Pubmed]
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  4. Role of genetic polymorphism of human plasma paraoxonase/arylesterase in hydrolysis of the insecticide metabolites chlorpyrifos oxon and paraoxon. Furlong, C.E., Richter, R.J., Seidel, S.L., Motulsky, A.G. Am. J. Hum. Genet. (1988) [Pubmed]
  5. The interaction of the phosphorothioate insecticides chlorpyrifos and parathion and their oxygen analogues with bovine serum albumin. Sultatos, L.G., Basker, K.M., Shao, M., Murphy, S.D. Mol. Pharmacol. (1984) [Pubmed]
  6. Paradoxical effects of prenatal acetylcholinesterase blockade on neuro-behavioral development and drug-induced stereotypies in reeler mutant mice. Laviola, G., Adriani, W., Gaudino, C., Marino, R., Keller, F. Psychopharmacology (Berl.) (2006) [Pubmed]
  7. Chlorpyrifos oxon binds directly to muscarinic receptors and inhibits cAMP accumulation in rat striatum. Huff, R.A., Corcoran, J.J., Anderson, J.K., Abou-Donia, M.B. J. Pharmacol. Exp. Ther. (1994) [Pubmed]
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  9. Comparison of chlorpyrifos-oxon and paraoxon acetylcholinesterase inhibition dynamics: potential role of a peripheral binding site. Kousba, A.A., Sultatos, L.G., Poet, T.S., Timchalk, C. Toxicol. Sci. (2004) [Pubmed]
  10. Age-Related Brain Cholinesterase Inhibition Kinetics following In Vitro Incubation with Chlorpyrifos-Oxon and Diazinon-Oxon. Kousba, A.A., Poet, T.S., Timchalk, C. Toxicol. Sci. (2007) [Pubmed]
  11. Developmental cholinotoxicants: nicotine and chlorpyrifos. Slotkin, T.A. Environ. Health Perspect. (1999) [Pubmed]
  12. Chlorpyrifos, chlorpyrifos-oxon, and diisopropylfluorophosphate inhibit kinesin-dependent microtubule motility. Gearhart, D.A., Sickles, D.W., Buccafusco, J.J., Prendergast, M.A., Terry, A.V. Toxicol. Appl. Pharmacol. (2007) [Pubmed]
  13. Blood acylpeptide hydrolase activity is a sensitive marker for exposure to some organophosphate toxicants. Quistad, G.B., Klintenberg, R., Casida, J.E. Toxicol. Sci. (2005) [Pubmed]
  14. The effect of chlorpyrifos and chlorpyrifos-oxon on brain cholinesterase, muscarinic receptor binding, and neurotrophin levels in rats following early postnatal exposure. Betancourt, A.M., Carr, R.L. Toxicol. Sci. (2004) [Pubmed]
  15. Identification and isolation of two rat serum proteins with A-esterase activity toward paraoxon and chlorpyrifos-oxon. Pond, A.L., Coyne, C.P., Chambers, H.W., Chambers, J.E. Biochem. Pharmacol. (1996) [Pubmed]
  16. Serum paraoxonase and its influence on paraoxon and chlorpyrifos-oxon toxicity in rats. Costa, L.G., McDonald, B.E., Murphy, S.D., Omenn, G.S., Richter, R.J., Motulsky, A.G., Furlong, C.E. Toxicol. Appl. Pharmacol. (1990) [Pubmed]
  17. In vitro effects of organophosphorus anticholinesterases on muscarinic receptor-mediated inhibition of acetylcholine release in rat striatum. Liu, J., Chakraborti, T., Pope, C. Toxicol. Appl. Pharmacol. (2002) [Pubmed]
  18. Degradation of chlorpyrifos in aqueous chlorine solutions: pathways, kinetics, and modeling. Duirk, S.E., Collette, T.W. Environ. Sci. Technol. (2006) [Pubmed]
  19. Inhibition of acetylcholinesterase and butyrylcholinesterase by chlorpyrifos-oxon. Amitai, G., Moorad, D., Adani, R., Doctor, B.P. Biochem. Pharmacol. (1998) [Pubmed]
  20. Inhibition and activation of the human liver microsomal and human cytochrome P450 3A4 metabolism of testosterone by deployment-related chemicals. Usmani, K.A., Rose, R.L., Hodgson, E. Drug Metab. Dispos. (2003) [Pubmed]
  21. In vitro human metabolism and interactions of repellent N,N-diethyl-m-toluamide. Usmani, K.A., Rose, R.L., Goldstein, J.A., Taylor, W.G., Brimfield, A.A., Hodgson, E. Drug Metab. Dispos. (2002) [Pubmed]
  22. Role of paraoxonase (PON1) status in pesticide sensitivity: genetic and temporal determinants. Furlong, C.E., Cole, T.B., Jarvik, G.P., Pettan-Brewer, C., Geiss, G.K., Richter, R.J., Shih, D.M., Tward, A.D., Lusis, A.J., Costa, L.G. Neurotoxicology (2005) [Pubmed]
  23. Metabolism of chlorpyrifos by human cytochrome P450 isoforms and human, mouse, and rat liver microsomes. Tang, J., Cao, Y., Rose, R.L., Brimfield, A.A., Dai, D., Goldstein, J.A., Hodgson, E. Drug Metab. Dispos. (2001) [Pubmed]
  24. Naked DNA prevents soman intoxication. Fu, A.L., Wang, Y.X., Sun, M.J. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  25. Factors affecting the hepatic biotransformation of the phosphorothioate pesticide chlorpyrifos. Sultatos, L.G. Toxicology (1988) [Pubmed]
  26. An insensitive acetylcholinesterase confers resistance to methomyl in the beet armyworm Spodoptera exigua (Lepidoptera: Noctuidae). Byrne, F.J., Toscano, N.C. J. Econ. Entomol. (2001) [Pubmed]
  27. Effect of chlorpyrifos on efflux transporter gene expression and function in Caco-2 cells. Agarwala, S., Chen, W., Cook, T.J. Toxicology in vitro : an international journal published in association with BIBRA. (2004) [Pubmed]
  28. Flow-injection amperometric determination of pesticides on the basis of their inhibition of immobilized acetylcholinesterases of different origin. Jeanty, G., Wojciechowska, A., Marty, J.L., Trojanowicz, M. Analytical and bioanalytical chemistry. (2002) [Pubmed]
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