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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

NCEH1  -  neutral cholesterol ester hydrolase 1

Homo sapiens

Synonyms: AADACL1, Arylacetamide deacetylase-like 1, KIAA1363, NCEH, Neutral cholesterol ester hydrolase 1
 
 
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High impact information on AADACL1

  • These invasiveness-associated enzymes included urokinase, a secreted serine protease with a recognized role in tumor progression, and a membrane-associated hydrolase KIAA1363, for which no previous link to cancer had been made [1].
  • This approach determined that KIAA1363, an uncharacterized enzyme highly elevated in aggressive cancer cells, serves as a central node in an ether lipid signaling network that bridges platelet-activating factor and lysophosphatidic acid [2].
  • Inactivation of KIAA1363 disrupted ether lipid metabolism in cancer cells and impaired cell migration and tumor growth in vivo [2].
  • KIAA1363 is sensitive to numerous OPs, including two O-4-nitrophenyl compounds (IC50 3-4 nM) [3].

References

  1. Enzyme activity profiles of the secreted and membrane proteome that depict cancer cell invasiveness. Jessani, N., Liu, Y., Humphrey, M., Cravatt, B.F. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  2. An Enzyme that Regulates Ether Lipid Signaling Pathways in Cancer Annotated by Multidimensional Profiling. Chiang, K.P., Niessen, S., Saghatelian, A., Cravatt, B.F. Chem. Biol. (2006) [Pubmed]
  3. Each lipase has a unique sensitivity profile for organophosphorus inhibitors. Quistad, G.B., Liang, S.N., Fisher, K.J., Nomura, D.K., Casida, J.E. Toxicol. Sci. (2006) [Pubmed]
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