The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

NCEH1  -  neutral cholesterol ester hydrolase 1

Homo sapiens

Synonyms: AADACL1, Arylacetamide deacetylase-like 1, KIAA1363, NCEH, Neutral cholesterol ester hydrolase 1
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on AADACL1

  • These invasiveness-associated enzymes included urokinase, a secreted serine protease with a recognized role in tumor progression, and a membrane-associated hydrolase KIAA1363, for which no previous link to cancer had been made [1].
  • This approach determined that KIAA1363, an uncharacterized enzyme highly elevated in aggressive cancer cells, serves as a central node in an ether lipid signaling network that bridges platelet-activating factor and lysophosphatidic acid [2].
  • Inactivation of KIAA1363 disrupted ether lipid metabolism in cancer cells and impaired cell migration and tumor growth in vivo [2].
  • KIAA1363 is sensitive to numerous OPs, including two O-4-nitrophenyl compounds (IC50 3-4 nM) [3].


  1. Enzyme activity profiles of the secreted and membrane proteome that depict cancer cell invasiveness. Jessani, N., Liu, Y., Humphrey, M., Cravatt, B.F. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  2. An Enzyme that Regulates Ether Lipid Signaling Pathways in Cancer Annotated by Multidimensional Profiling. Chiang, K.P., Niessen, S., Saghatelian, A., Cravatt, B.F. Chem. Biol. (2006) [Pubmed]
  3. Each lipase has a unique sensitivity profile for organophosphorus inhibitors. Quistad, G.B., Liang, S.N., Fisher, K.J., Nomura, D.K., Casida, J.E. Toxicol. Sci. (2006) [Pubmed]
WikiGenes - Universities