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Gene Review

sisA  -  sisterless A

Drosophila melanogaster

Synonyms: CG1641, Dmel\CG1641, Protein sisterless A, sis A, sis a, ...
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High impact information on sisA

  • Two potent indicators of X-chromosome dose are sisterless-a (sis-a) and sisterless-b (sis-b) [1].
  • In D. melanogaster, a set of 'X:A numerator genes', which includes sisterlessA (sisA), determines sex by controlling the transcription of Sex-lethal (Sxl) [2].
  • In the absence of sisA, endoderm migration and midgut formation are blocked, suggesting that the yolk cell may have a direct role in larval gut development [3].

Biological context of sisA

  • During sex determination, the sisterlessA (sisA) gene functions as one of four X:A numerator elements that set the alternative male or female regulatory states of the switch gene Sex-lethal [3].


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