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Gene Review

TK2104  -  deoxyribose-phosphate aldolase

Thermococcus kodakarensis KOD1

 
 
 
 
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High impact information on TK2104

  • A search of the genome sequence of this strain revealed the presence of a closely related orthologue (TK2104) of bacterial DERA genes while no orthologue related to previously characterized PPM genes could be detected [1].
 

Associations of TK2104 with chemical compounds

  • Our results clearly indicate the presence of a metabolic link between pentoses and central carbon metabolism in T. kodakaraensis, providing an alternative route for pentose biosynthesis through the functions of DERA and a structurally novel PPM [1].
  • Numerous bacteria and mammalian cells harbor two enzymes, phosphopentomutase (PPM) and 2-deoxyribose 5-phosphate aldolase (DERA), involved in the interconversion between nucleosides and central carbon metabolism [1].

References

 
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