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Gene Review

Krn  -  Keren

Drosophila melanogaster

Synonyms: CG32179, CG8056, CT19073, Dmel\CG32179, Ker, ...
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High impact information on Krn

  • Examining Spi/Krn chimeric and deletion constructs implicates the Spi cytoplasmic domain in inhibiting its basal activity [1].
  • Keren activates the EGF receptor in vivo, providing strong evidence that it is a true ligand [2].
  • Since some DER phenotypes are not mimicked by any of its known activating ligands, we identified an additional ligand by database searches, and termed it Keren (Krn) [1].

Biological context of Krn


Other interactions of Krn


  1. Keren, a new ligand of the Drosophila epidermal growth factor receptor, undergoes two modes of cleavage. Reich, A., Shilo, B.Z. EMBO J. (2002) [Pubmed]
  2. A family of Rhomboid intramembrane proteases activates all Drosophila membrane-tethered EGF ligands. Urban, S., Lee, J.R., Freeman, M. EMBO J. (2002) [Pubmed]
  3. Multiple EGFR ligands participate in guiding migrating border cells. McDonald, J.A., Pinheiro, E.M., Kadlec, L., Schupbach, T., Montell, D.J. Dev. Biol. (2006) [Pubmed]
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