High impact information on Krn

• Examining Spi/Krn chimeric and deletion constructs implicates the Spi cytoplasmic domain in inhibiting its basal activity [1].
• Keren activates the EGF receptor in vivo, providing strong evidence that it is a true ligand [2].
• Since some DER phenotypes are not mimicked by any of its known activating ligands, we identified an additional ligand by database searches, and termed it Keren (Krn) [1].

Biological context of Krn

• In addition, only Keren and Spitz were expressed at the appropriate stage in the oocyte, the target of border cell migration [3].

Other interactions of Krn

• While Spi is retained in the ER, the retention of Krn is only partial [1].
• Keren, a new ligand of the Drosophila epidermal growth factor receptor, undergoes two modes of cleavage [1].
• Drosophila has three membrane-tethered epidermal growth factor (EGF)-like proteins: Spitz, Gurken and Keren [2].

References