Gene Review:
spi - spitz
Drosophila melanogaster
Synonyms:
CG10334, CT29014, Dmel\CG10334, EP(2)2378, Protein spitz, ...
- EGF receptor signalling protects smooth-cuticle cells from apoptosis during Drosophila ventral epidermis development. Urban, S., Brown, G., Freeman, M. Development (2004)
- Drosophila rhomboid-1 defines a family of putative intramembrane serine proteases. Urban, S., Lee, J.R., Freeman, M. Cell (2001)
- Regulated intracellular ligand transport and proteolysis control EGF signal activation in Drosophila. Lee, J.R., Urban, S., Garvey, C.F., Freeman, M. Cell (2001)
- Twin peaks: Spitz and Argos star in patterning of the Drosophila egg. Stevens, L. Cell (1998)
- The Drosophila rhomboid gene mediates the localized formation of wing veins and interacts genetically with components of the EGF-R signaling pathway. Sturtevant, M.A., Roark, M., Bier, E. Genes Dev. (1993)
- The interaction between the Drosophila secreted protein argos and the epidermal growth factor receptor inhibits dimerization of the receptor and binding of secreted spitz to the receptor. Jin, M.H., Sawamoto, K., Ito, M., Okano, H. Mol. Cell. Biol. (2000)
- Several levels of EGF receptor signaling during photoreceptor specification in wild-type, Ellipse, and null mutant Drosophila. Lesokhin, A.M., Yu, S.Y., Katz, J., Baker, N.E. Dev. Biol. (1999)
- The Drosophila spitz gene encodes a putative EGF-like growth factor involved in dorsal-ventral axis formation and neurogenesis. Rutledge, B.J., Zhang, K., Bier, E., Jan, Y.N., Perrimon, N. Genes Dev. (1992)
- Argos and Spitz group genes function to regulate midline glial cell number in Drosophila embryos. Stemerdink, C., Jacobs, J.R. Development (1997)
- Secreted Spitz triggers the DER signaling pathway and is a limiting component in embryonic ventral ectoderm determination. Schweitzer, R., Shaharabany, M., Seger, R., Shilo, B.Z. Genes Dev. (1995)
- The Drosophila embryonic midline is the site of Spitz processing, and induces activation of the EGF receptor in the ventral ectoderm. Golembo, M., Raz, E., Shilo, B.Z. Development (1996)
- The Drosophila TGF alpha homolog Spitz acts in photoreceptor recruitment in the developing retina. Tio, M., Moses, K. Development (1997)
- Palmitoylation of the EGFR ligand Spitz by Rasp increases Spitz activity by restricting its diffusion. Miura, G.I., Buglino, J., Alvarado, D., Lemmon, M.A., Resh, M.D., Treisman, J.E. Dev. Cell (2006)
- The spitz gene is required for photoreceptor determination in the Drosophila eye where it interacts with the EGF receptor. Freeman, M. Mech. Dev. (1994)
- Argos mutants define an affinity threshold for spitz inhibition in vivo. Alvarado, D., Evans, T.A., Sharma, R., Lemmon, M.A., Duffy, J.B. J. Biol. Chem. (2006)
- Small wing PLCgamma is required for ER retention of cleaved Spitz during eye development in Drosophila. Schlesinger, A., Kiger, A., Perrimon, N., Shilo, B.Z. Dev. Cell (2004)
- Intracellular trafficking by Star regulates cleavage of the Drosophila EGF receptor ligand Spitz. Tsruya, R., Schlesinger, A., Reich, A., Gabay, L., Sapir, A., Shilo, B.Z. Genes Dev. (2002)
- Senseless represses nuclear transduction of Egfr pathway activation. Frankfort, B.J., Mardon, G. Development (2004)
- Insect oenocytes: a model system for studying cell-fate specification by Hox genes. Gould, A.P., Elstob, P.R., Brodu, V. J. Anat. (2001)
- Tissue-specific regulation of vein/EGF receptor signaling in Drosophila. Wessells, R.J., Grumbling, G., Donaldson, T., Wang, S.H., Simcox, A. Dev. Biol. (1999)
- Keren, a new ligand of the Drosophila epidermal growth factor receptor, undergoes two modes of cleavage. Reich, A., Shilo, B.Z. EMBO J. (2002)
- The hierarchical relationship among the spitz/Egfr signaling genes in cell fate determination in the Drosophila ventral neuroectoderm. Chang, J., Jeon, S.H., Kim, S.H. Mol. Cells (2003)