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Gene Review:

Cia1 - Collagen induced arthritis QTL 1

Rattus norvegicus

Griffiths, M.M. et al., Dahlman, I. et al., Remmers, E.F. et al.

Dahlman, Lorentzen, de Graaf, Stefferl, Linington, Luthman, Olsson,

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High impact information on Cia1

Not surprisingly, we identified a major susceptibility factor, Cia1, on chromosome 20 in the vicinity of the rat major histocompatibility complex (MHC) [1].
Of 10 CIA QTLs previously identified in (DA x F344) and (DA x ACI) rats, only Cia1 in the major histocompatibility complex and a region coincident to Cia5 on chromosome 10 (LOD >8.0) influenced CIA severity in (DA x BN)F2 rats [2].
The DA allele at markers in Cia3 (collagen-induced arthritis QTL) on chromosome 4 is associated with more severe EAE and high levels of anti-MOG antibodies of the IgG2c subclass [3].

References

A genome scan localizes five non-MHC loci controlling collagen-induced arthritis in rats. Remmers, E.F., Longman, R.E., Du, Y., O'Hare, A., Cannon, G.W., Griffiths, M.M., Wilder, R.L. Nat. Genet. (1996) [Pubmed]
Identification of four new quantitative trait loci regulating arthritis severity and one new quantitative trait locus regulating autoantibody production in rats with collagen-induced arthritis. Griffiths, M.M., Wang, J., Joe, B., Dracheva, S., Kawahito, Y., Shepard, J.S., Reese, V.R., McCall-Vining, S., Hashiramoto, A., Cannon, G.W., Remmers, E.F., Wilder, R.L. Arthritis Rheum. (2000) [Pubmed]
Quantitative trait loci disposing for both experimental arthritis and encephalomyelitis in the DA rat; impact on severity of myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis and antibody isotype pattern. Dahlman, I., Lorentzen, J.C., de Graaf, K.L., Stefferl, A., Linington, C., Luthman, H., Olsson, T. Eur. J. Immunol. (1998) [Pubmed]

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