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Gene Review:

Cia5 - Collagen induced arthritis QTL 5

Rattus norvegicus

Brenner, M., Griffiths, M.M. et al., Brenner, M. et al., Remmers, E.F. et al.

Max Brenner,

High impact information on Cia5

Cia27 also regulates CIA but in DA x ACI, and partially overlaps with Cia5 [1].
Cia5 subcongenic strains were generated and studied in PIA and CIA , revealing three major arthritis genes that differentially regulate disease severity, levels of auto-antibodies, pannus formation, and joint damage in CIA and PIA. These are Cia5a, Cia5d, and a third unnamed locus [2], later renamed by RGD to Cia28/Pia25, Pia26, and Cia29, respectively .
F344 alleles at the Cia3 and Cia5 regions of chromosomes 4 and 10 reduced CIA severity relative to that observed in DA rats [3].
Of 10 CIA QTLs previously identified in (DA x F344) and (DA x ACI) rats, only Cia1 in the major histocompatibility complex and a region coincident to Cia5 on chromosome 10 (LOD >8.0) influenced CIA severity in (DA x BN)F2 rats [4].
Cia5 was identified to regulate CIA severity in a linkage study of (DA x F344) F2 [5].

References

Cia27 is a novel non-MHC arthritis severity locus on rat chromosome 10 syntenic to the rheumatoid arthritis 17q22-q25 locus. Brenner, M., Laragione, T., Yarlett, N.C., Li, W., Mello, A., Gulko, P.S. Genes. Immun. (2006) [Pubmed]
The non-MHC quantitative trait locus Cia5 contains three major arthritis genes that differentially regulate disease severity, pannus formation, and joint damage in collagen- and pristane-induced arthritis. Brenner, M., Meng, H.C., Yarlett, N.C., Joe, B., Griffiths, M.M., Remmers, E.F., Wilder, R.L., Gulko, P.S. J. Immunol. (2005) [Pubmed]
Modulation of multiple experimental arthritis models by collagen-induced arthritis quantitative trait loci isolated in congenic rat lines: different effects of non-major histocompatibility complex quantitative trait loci in males and females. Remmers, E.F., Joe, B., Griffiths, M.M., Dobbins, D.E., Dracheva, S.V., Hashiramoto, A., Furuya, T., Salstrom, J.L., Wang, J., Gulko, P.S., Cannon, G.W., Wilder, R.L. Arthritis Rheum. (2002) [Pubmed]
Identification of four new quantitative trait loci regulating arthritis severity and one new quantitative trait locus regulating autoantibody production in rats with collagen-induced arthritis. Griffiths, M.M., Wang, J., Joe, B., Dracheva, S., Kawahito, Y., Shepard, J.S., Reese, V.R., McCall-Vining, S., Hashiramoto, A., Cannon, G.W., Remmers, E.F., Wilder, R.L. Arthritis Rheum. (2000) [Pubmed]
A genome scan localizes five non-MHC loci controlling collagen-induced arthritis in rats. Remmers, E.F., Longman, R.E., Du, Y., O'Hare, A., Cannon, G.W., Griffiths, M.M., Wilder, R.L. Nat. Genet. (1996) [Pubmed]

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