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Gene Review

Iddm8  -  Insulin dependent diabetes mellitus QTL 8

Rattus norvegicus

 
 
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Disease relevance of Iddm8

  • The rat diabetes susceptibility locus Iddm4 and at least one additional gene are required for autoimmune diabetes induced by viral infection [1].
 

High impact information on Iddm8

 

Analytical, diagnostic and therapeutic context of Iddm8

  • We have produced a radiation hybrid map of the Iddm4-region that includes a number of rat genes with their mouse and human orthologs [3].

References

  1. The rat diabetes susceptibility locus Iddm4 and at least one additional gene are required for autoimmune diabetes induced by viral infection. Blankenhorn, E.P., Rodemich, L., Martin-Fernandez, C., Leif, J., Greiner, D.L., Mordes, J.P. Diabetes (2005) [Pubmed]
  2. Genetic variation in the multifunctional transcription factor Yy1 and type 1 diabetes mellitus in the BB rat. Klöting, N., Klöting, I. Mol. Genet. Metab. (2004) [Pubmed]
  3. Comparative mapping of rat Iddm4 to segments on HSA7 and MMU6. Hornum, L., DeScipio, C., Markholst, H., Troutman, S.A., Novak, S., Leif, J., Greiner, D., Mordes, J.P., Blankenhorn, E.P. Mamm. Genome (2004) [Pubmed]
 
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