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MeSH Review

Diabetes Mellitus, Type 1

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Disease relevance of Diabetes Mellitus, Type 1


Psychiatry related information on Diabetes Mellitus, Type 1


High impact information on Diabetes Mellitus, Type 1


Chemical compound and disease context of Diabetes Mellitus, Type 1


Biological context of Diabetes Mellitus, Type 1


Anatomical context of Diabetes Mellitus, Type 1


Gene context of Diabetes Mellitus, Type 1

  • The role of Fas in autoimmune diabetes [30].
  • In autoimmune diabetes the transition from benign to pernicious insulitis requires an islet cell response to tumor necrosis factor alpha [31].
  • These studies demonstrate that costimulatory signals play an important role in the autoimmune process, and that different members of the B7 family have distinct regulatory functions during the development of autoimmune diabetes [32].
  • Early treatment with LTbetaR-Ig prevented insulitis and IDDM, suggesting that LT plays a critical role in the insulitis development [33].
  • It is concluded that expression of a hybrid insulin/IL-1ra gene confers resistance to IL-1 and that this technique may be used to elucidate the role of IL-1 in autoimmune disorders such as insulin-dependent diabetes mellitus [34].

Analytical, diagnostic and therapeutic context of Diabetes Mellitus, Type 1


  1. Plasma glucose concentrations at the onset of hypoglycemic symptoms in patients with poorly controlled diabetes and in nondiabetics. Boyle, P.J., Schwartz, N.S., Shah, S.D., Clutter, W.E., Cryer, P.E. N. Engl. J. Med. (1988) [Pubmed]
  2. Improvement of gastric emptying in diabetic gastroparesis by erythromycin. Preliminary studies. Janssens, J., Peeters, T.L., Vantrappen, G., Tack, J., Urbain, J.L., De Roo, M., Muls, E., Bouillon, R. N. Engl. J. Med. (1990) [Pubmed]
  3. Effect of beta-blockade on mortality among high-risk and low-risk patients after myocardial infarction. Gottlieb, S.S., McCarter, R.J., Vogel, R.A. N. Engl. J. Med. (1998) [Pubmed]
  4. Development of insulin-dependent diabetes mellitus does not depend on specific expression of the human endogenous retrovirus HERV-K. Löwer, R., Tönjes, R.R., Boller, K., Denner, J., Kaiser, B., Phelps, R.C., Löwer, J., Kurth, R., Badenhoop, K., Donner, H., Usadel, K.H., Miethke, T., Lapatschek, M., Wagner, H. Cell (1998) [Pubmed]
  5. New HLA DNA polymorphisms associated with autoimmune diseases. Festenstein, H., Awad, J., Hitman, G.A., Cutbush, S., Groves, A.V., Cassell, P., Ollier, W., Sachs, J.A. Nature (1986) [Pubmed]
  6. Expressed emotion and glucose control in insulin-dependent diabetes mellitus. Koenigsberg, H.W., Klausner, E., Pelino, D., Rosnick, P., Campbell, R. The American journal of psychiatry. (1993) [Pubmed]
  7. Binge eating and purging in young women with IDDM. Stancin, T., Link, D.L., Reuter, J.M. Diabetes Care (1989) [Pubmed]
  8. Children's self-reports of psychologic adjustment and coping strategies during first year of insulin-dependent diabetes mellitus. Kovacs, M., Brent, D., Steinberg, T.F., Paulauskas, S., Reid, J. Diabetes Care (1986) [Pubmed]
  9. Effects of a physical activity program on metabolic control and cardiovascular fitness in children with insulin-dependent diabetes mellitus. Campaigne, B.N., Gilliam, T.B., Spencer, M.L., Lampman, R.M., Schork, M.A. Diabetes Care (1984) [Pubmed]
  10. Stress in parents of children with diabetes mellitus. Hauenstein, E.J., Marvin, R.S., Snyder, A.L., Clarke, W.L. Diabetes Care (1989) [Pubmed]
  11. Molecular mechanisms of lymphocyte-mediated cytotoxicity and their role in immunological protection and pathogenesis in vivo. Kägi, D., Ledermann, B., Bürki, K., Zinkernagel, R.M., Hengartner, H. Annu. Rev. Immunol. (1996) [Pubmed]
  12. Driven to autoimmunity: the nod mouse. Gallegos, A.M., Bevan, M.J. Cell (2004) [Pubmed]
  13. Cblb is a major susceptibility gene for rat type 1 diabetes mellitus. Yokoi, N., Komeda, K., Wang, H.Y., Yano, H., Kitada, K., Saitoh, Y., Seino, Y., Yasuda, K., Serikawa, T., Seino, S. Nat. Genet. (2002) [Pubmed]
  14. A novel subtype of type 1 diabetes mellitus characterized by a rapid onset and an absence of diabetes-related antibodies. Osaka IDDM Study Group. Imagawa, A., Hanafusa, T., Miyagawa, J., Matsuzawa, Y. N. Engl. J. Med. (2000) [Pubmed]
  15. A humanized model for multiple sclerosis using HLA-DR2 and a human T-cell receptor. Madsen, L.S., Andersson, E.C., Jansson, L., krogsgaard, M., Andersen, C.B., Engberg, J., Strominger, J.L., Svejgaard, A., Hjorth, J.P., Holmdahl, R., Wucherpfennig, K.W., Fugger, L. Nat. Genet. (1999) [Pubmed]
  16. Abnormal glucose counterregulation in insulin-dependent diabetes mellitus. Davidson, M.B. N. Engl. J. Med. (1984) [Pubmed]
  17. Analysis of HLA-DQ genotypes and susceptibility in insulin-dependent diabetes mellitus. Baisch, J.M., Weeks, T., Giles, R., Hoover, M., Stastny, P., Capra, J.D. N. Engl. J. Med. (1990) [Pubmed]
  18. The effect of angiotensin-converting-enzyme inhibition on diabetic nephropathy. The Collaborative Study Group. Lewis, E.J., Hunsicker, L.G., Bain, R.P., Rohde, R.D. N. Engl. J. Med. (1993) [Pubmed]
  19. Immunosuppression with azathioprine and prednisone in recent-onset insulin-dependent diabetes mellitus. Silverstein, J., Maclaren, N., Riley, W., Spillar, R., Radjenovic, D., Johnson, S. N. Engl. J. Med. (1988) [Pubmed]
  20. The minisatellite in the diabetes susceptibility locus IDDM2 regulates insulin transcription. Kennedy, G.C., German, M.S., Rutter, W.J. Nat. Genet. (1995) [Pubmed]
  21. Linkage and association between insulin-dependent diabetes mellitus (IDDM) susceptibility and markers near the glucokinase gene on chromosome 7. Rowe, R.E., Wapelhorst, B., Bell, G.I., Risch, N., Spielman, R.S., Concannon, P. Nat. Genet. (1995) [Pubmed]
  22. A second-generation screen of the human genome for susceptibility to insulin-dependent diabetes mellitus. Concannon, P., Gogolin-Ewens, K.J., Hinds, D.A., Wapelhorst, B., Morrison, V.A., Stirling, B., Mitra, M., Farmer, J., Williams, S.R., Cox, N.J., Bell, G.I., Risch, N., Spielman, R.S. Nat. Genet. (1998) [Pubmed]
  23. A search for type 1 diabetes susceptibility genes in families from the United Kingdom. Mein, C.A., Esposito, L., Dunn, M.G., Johnson, G.C., Timms, A.E., Goy, J.V., Smith, A.N., Sebag-Montefiore, L., Merriman, M.E., Wilson, A.J., Pritchard, L.E., Cucca, F., Barnett, A.H., Bain, S.C., Todd, J.A. Nat. Genet. (1998) [Pubmed]
  24. Linkage of faulty major histocompatibility complex class I to autoimmune diabetes. Faustman, D., Li, X.P., Lin, H.Y., Fu, Y.E., Eisenbarth, G., Avruch, J., Guo, J. Science (1991) [Pubmed]
  25. Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus. Vafiadis, P., Bennett, S.T., Todd, J.A., Nadeau, J., Grabs, R., Goodyer, C.G., Wickramasinghe, S., Colle, E., Polychronakos, C. Nat. Genet. (1997) [Pubmed]
  26. Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase. Baekkeskov, S., Aanstoot, H.J., Christgau, S., Reetz, A., Solimena, M., Cascalho, M., Folli, F., Richter-Olesen, H., De Camilli, P., Camilli, P.D. Nature (1990) [Pubmed]
  27. Signalling through CD30 protects against autoimmune diabetes mediated by CD8 T cells. Kurts, C., Carbone, F.R., Krummel, M.F., Koch, K.M., Miller, J.F., Heath, W.R. Nature (1999) [Pubmed]
  28. Major histocompatibility complex class I molecule expression is normal on peripheral blood lymphocytes from patients with insulin-dependent diabetes mellitus. Hao, W., Gladstone, P., Engardt, S., Greenbaum, C., Palmer, J.P. J. Clin. Invest. (1996) [Pubmed]
  29. Mononuclear cell infiltration and its relation to the expression of major histocompatibility complex antigens and adhesion molecules in pancreas biopsy specimens from newly diagnosed insulin-dependent diabetes mellitus patients. Itoh, N., Hanafusa, T., Miyazaki, A., Miyagawa, J., Yamagata, K., Yamamoto, K., Waguri, M., Imagawa, A., Tamura, S., Inada, M. J. Clin. Invest. (1993) [Pubmed]
  30. The role of Fas in autoimmune diabetes. Chervonsky, A.V., Wang, Y., Wong, F.S., Visintin, I., Flavell, R.A., Janeway, C.A., Matis, L.A. Cell (1997) [Pubmed]
  31. In autoimmune diabetes the transition from benign to pernicious insulitis requires an islet cell response to tumor necrosis factor alpha. Pakala, S.V., Chivetta, M., Kelly, C.B., Katz, J.D. J. Exp. Med. (1999) [Pubmed]
  32. Differential effects of anti-B7-1 and anti-B7-2 monoclonal antibody treatment on the development of diabetes in the nonobese diabetic mouse. Lenschow, D.J., Ho, S.C., Sattar, H., Rhee, L., Gray, G., Nabavi, N., Herold, K.C., Bluestone, J.A. J. Exp. Med. (1995) [Pubmed]
  33. Reversal of spontaneous autoimmune insulitis in nonobese diabetic mice by soluble lymphotoxin receptor. Wu, Q., Salomon, B., Chen, M., Wang, Y., Hoffman, L.M., Bluestone, J.A., Fu, Y.X. J. Exp. Med. (2001) [Pubmed]
  34. Expression of an insulin/interleukin-1 receptor antagonist hybrid gene in insulin-producing cell lines (HIT-T15 and NIT-1) confers resistance against interleukin-1-induced nitric oxide production. Welsh, N., Bendtzen, K., Welsh, M. J. Clin. Invest. (1995) [Pubmed]
  35. HLA class II alleles and susceptibility and resistance to insulin dependent diabetes mellitus in Mexican-American families. Erlich, H.A., Zeidler, A., Chang, J., Shaw, S., Raffel, L.J., Klitz, W., Beshkov, Y., Costin, G., Pressman, S., Bugawan, T. Nat. Genet. (1993) [Pubmed]
  36. Lack of immune responsiveness to bovine serum albumin in insulin-dependent diabetes. Atkinson, M.A., Bowman, M.A., Kao, K.J., Campbell, L., Dush, P.J., Shah, S.C., Simell, O., Maclaren, N.K. N. Engl. J. Med. (1993) [Pubmed]
  37. Induction of autoimmune diabetes by oral administration of autoantigen. Blanas, E., Carbone, F.R., Allison, J., Miller, J.F., Heath, W.R. Science (1996) [Pubmed]
  38. Determinant spreading of T helper cell 2 (Th2) responses to pancreatic islet autoantigens. Tian, J., Lehmann, P.V., Kaufman, D.L. J. Exp. Med. (1997) [Pubmed]
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