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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

NR2F1  -  nuclear receptor subfamily 2, group F,...

Bos taurus

Synonyms: COUP-TF, COUP-TFI
 
 
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High impact information on NR2F1

  • COUP-TF protein was readily detectable in nonstimulated cells, and AngII markedly reduced its expression in a time- and concentration-dependent manner (IC50 = 1 nm), to 46 +/- 4.4% of control levels after 6 h, (n = 3; P < 0.01) [1].
  • This repression was paralleled by a marked decrease in COUP-TF mRNA levels, reaching 18 +/- 8.8% of controls (n = 3, P < 0.01) after 6 h and by a 20-fold increase in aldosterone output [1].
  • It was found that DAX-1 and COUP-TF mRNA levels were unaffected by treatment with ACTH or forskolin [2].
 

Analytical, diagnostic and therapeutic context of NR2F1

References

  1. Chicken ovalbumin upstream promoter-transcription factor is a negative regulator of steroidogenesis in bovine adrenal glomerulosa cells. Buholzer, C.F., Arrighi, J.F., Abraham, S., Piguet, V., Capponi, A.M., Casal, A.J. Mol. Endocrinol. (2005) [Pubmed]
  2. Expression of three negative regulators of CYP17 gene transcription in adrenocortical cells. Lehmann, T., Biernacka-Lukanty, J., Trzeciak, W.H. Endocr. Res. (2000) [Pubmed]
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