The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

NR2F1  -  nuclear receptor subfamily 2, group F,...

Homo sapiens

Synonyms: BBOAS, BBSOAS, COUP transcription factor 1, COUP transcription factor I, COUP-TF I, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of NR2F1


High impact information on NR2F1


Chemical compound and disease context of NR2F1


Biological context of NR2F1


Anatomical context of NR2F1

  • In addition, hCG treatment significantly reduced the inhibition of rLHR gene in granulosa cells and also decreased EAR2 and EAR3/COUP-TFI protein levels [15].
  • These in vitro data indicate that COUP-TF proteins and SMRT modulate PPARgamma-mediated LPL transcription in the 293T cell line [16].
  • Synergistic activation of the Atlantic salmon hepatocyte nuclear factor (HNF) 1 promoter by the orphan nuclear receptors HNF4 and chicken ovalbumin upstream promoter transcription factor I (COUP-TFI) [17].
  • To address this apparent paradox, the current study examined the effect of two classes of candidate comodulatory proteins, COUP-TF (chicken ovalbumin upstream promoter transcriptional factor) and the corepressor SMRT (silencing mediator of retinoic acid receptor and thyroid receptor) [16].
  • Expression profiles of COUP-TF, DAX-1, and SF-1 in the human adrenal gland and adrenocortical tumors: possible implications in steroidogenesis [18].

Associations of NR2F1 with chemical compounds


Physical interactions of NR2F1

  • We also report that AHR interacts with COUP-TF in transfected CV-1 cells [2].
  • These results demonstrate that CTIP1 is a sequence-specific DNA binding protein and a bona fide transcriptional repressor that is capable of functioning independently of COUP-TF family members [22].
  • Conversely, COUP-TF enhanced the ERE binding of purified E2-ER, but did not affect TAz-ER-ERE binding [23].
  • By mutation analysis, we demonstrate that the effect of COUP-TF requires its binding to a DR-8 element present in the RARbeta promoter [24].
  • We further demonstrate that NF-IL6 physically interacts with the nuclear receptor chicken ovalbumin upstream promoter transcription factor (COUP-TF), via its DNA binding domain, in vitro and in cells, which results in mutual transcriptional repression [25].

Regulatory relationships of NR2F1

  • Notably, COUP-TFI activated rather than repressed several target genes including the human CYP11B2 gene promoter, the results of which were opposite to those of the CYP17 promoter [26].
  • Co-transfection of ER-expressing MCF-7 human breast cancer cells with an expression vector for COUP-TFI resulted in a dose-dependent inhibition of E2-induced expression of a luciferase reporter gene under the control of three tandem copies of EREc38 [20].
  • We report that CTIP2 represses Sp1- and COUP-TF-mediated activation of HIV-1 gene transcription and viral replication as a result of physical interactions with COUP-TF and Sp1 in microglial nuclei [27].
  • In a transient transfection assay, COUP-TF strongly induced transcriptional activity of the RARbeta promoter in a RA- and RARalpha-dependent manner [24].
  • In human lung cancer cell lines, COUP-TF is highly expressed in RA-sensitive cell lines while nur77 expression is associated with RA resistance [4].

Other interactions of NR2F1

  • The orphan receptor ARP-1/COUP-TFII, a member of the chicken ovalbumin upstream promoter transcription factor (COUP-TF) subfamily of nuclear receptors, strongly represses transcriptional activity of numerous genes, including several apolipoprotein-encoding genes [28].
  • Although S300-II does not bind DNA selectively, it stabilizes the binding of COUP-TF to its ciselement (Tsai, S. Y., Sagami, I., Wang, H., Tsai, M.-J., and O'Malley, B. W. (1987) Cell 50, 701-709) [29].
  • The aryl hydrocarbon receptor interacts with estrogen receptor alpha and orphan receptors COUP-TFI and ERRalpha1 [2].
  • In summary, the results indicate that co-localization of COUP-TF, DAX-1, and SF-1 in NL was lost in adrenocortical tumors and that these orphan receptors play an important role in the regulation of steroidogenesis in human adrenals [18].
  • We report that AHR interacts directly with ERalpha, COUP-TF, and ERRalpha1, in a ligand-specific manner in vitro [2].

Analytical, diagnostic and therapeutic context of NR2F1


  1. COUP-TFI expression in human adrenocortical adenomas: possible role in steroidogenesis. Shibata, H., Ando, T., Suzuki, T., Kurihara, I., Hayashi, K., Hayashi, M., Saito, I., Murai, M., Saruta, T. J. Clin. Endocrinol. Metab. (1998) [Pubmed]
  2. The aryl hydrocarbon receptor interacts with estrogen receptor alpha and orphan receptors COUP-TFI and ERRalpha1. Klinge, C.M., Kaur, K., Swanson, H.I. Arch. Biochem. Biophys. (2000) [Pubmed]
  3. Nuclear receptors and co-regulators in adrenal tumors. Shibata, H., Kobayashi, S., Kurihara, I., Saito, I., Saruta, T. Horm. Res. (2003) [Pubmed]
  4. Modulation of retinoic acid sensitivity in lung cancer cells through dynamic balance of orphan receptors nur77 and COUP-TF and their heterodimerization. Wu, Q., Li, Y., Liu, R., Agadir, A., Lee, M.O., Liu, Y., Zhang, X. EMBO J. (1997) [Pubmed]
  5. COUP-TF and Sp1 interact and cooperate in the transcriptional activation of the human immunodeficiency virus type 1 long terminal repeat in human microglial cells. Rohr, O., Aunis, D., Schaeffer, E. J. Biol. Chem. (1997) [Pubmed]
  6. Interactions between a DNA-binding transcription factor (COUP) and a non-DNA binding factor (S300-II). Tsai, S.Y., Sagami, I., Wang, H., Tsai, M.J., O'Malley, B.W. Cell (1987) [Pubmed]
  7. COUP transcription factor is a member of the steroid receptor superfamily. Wang, L.H., Tsai, S.Y., Cook, R.G., Beattie, W.G., Tsai, M.J., O'Malley, B.W. Nature (1989) [Pubmed]
  8. Chicken ovalbumin upstream promoter transcription factor, a transcriptional activator of HIV-1 gene expression in human brain cells. Sawaya, B.E., Rohr, O., Aunis, D., Schaeffer, E. J. Biol. Chem. (1996) [Pubmed]
  9. Chicken ovalbumin upstream promoter transcription factor (COUP-TF): an orphan steroid receptor with a specific pattern of differential expression in human ovarian cancer cell lines. Kieback, D.G., Runnebaum, I.B., Moebus, V.J., Kreienberg, R., McCamant, S.K., Edwards, C.L., Jones, L.A., Tsai, M.J., O'Malley, B.W. Gynecol. Oncol. (1993) [Pubmed]
  10. Expression of retinoid X receptors and COUP-TFI in a human salivary gland adenocarcinoma cell line. Kyakumoto, S., Nemoto, T., Sato, N., Ota, M. Biochem. Cell Biol. (1997) [Pubmed]
  11. Aromatase: a key molecule in the pathophysiology of endometriosis and a therapeutic target. Zeitoun, K.M., Bulun, S.E. Fertil. Steril. (1999) [Pubmed]
  12. Repression of the luteinizing hormone receptor gene promoter by cross talk among EAR3/COUP-TFI, Sp1/Sp3, and TFIIB. Zhang, Y., Dufau, M.L. Mol. Cell. Biol. (2003) [Pubmed]
  13. Transcription activation by the orphan nuclear receptor, chicken ovalbumin upstream promoter-transcription factor I (COUP-TFI). Definition of the domain involved in the glucocorticoid response of the phosphoenolpyruvate carboxykinase gene. Sugiyama, T., Wang, J.C., Scott, D.K., Granner, D.K. J. Biol. Chem. (2000) [Pubmed]
  14. Nuclear orphan receptors regulate transcription of the gene for the human luteinizing hormone receptor. Zhang, Y., Dufau, M.L. J. Biol. Chem. (2000) [Pubmed]
  15. EAR2 and EAR3/COUP-TFI regulate transcription of the rat LH receptor. Zhang, Y., Dufau, M.L. Mol. Endocrinol. (2001) [Pubmed]
  16. A corepressor and chicken ovalbumin upstream promoter transcriptional factor proteins modulate peroxisome proliferator-activated receptor-gamma2/retinoid X receptor alpha-activated transcription from the murine lipoprotein lipase promoter. Robinson, C.E., Wu, X., Nawaz, Z., Onãte, S.A., Gimble, J.M. Endocrinology (1999) [Pubmed]
  17. Synergistic activation of the Atlantic salmon hepatocyte nuclear factor (HNF) 1 promoter by the orphan nuclear receptors HNF4 and chicken ovalbumin upstream promoter transcription factor I (COUP-TFI). McNair, A., Cereghini, S., Brand, H., Smith, T., Breillat, C., Gannon, F. Biochem. J. (2000) [Pubmed]
  18. Expression profiles of COUP-TF, DAX-1, and SF-1 in the human adrenal gland and adrenocortical tumors: possible implications in steroidogenesis. Shibata, H., Ikeda, Y., Mukai, T., Morohashi, K., Kurihara, I., Ando, T., Suzuki, T., Kobayashi, S., Murai, M., Saito, I., Saruta, T. Mol. Genet. Metab. (2001) [Pubmed]
  19. The nuclear orphan receptors COUP-TF and ARP-1 positively regulate the trout estrogen receptor gene through enhancing autoregulation. Lazennec, G., Kern, L., Valotaire, Y., Salbert, G. Mol. Cell. Biol. (1997) [Pubmed]
  20. Chicken ovalbumin upstream promoter-transcription factor interacts with estrogen receptor, binds to estrogen response elements and half-sites, and inhibits estrogen-induced gene expression. Klinge, C.M., Silver, B.F., Driscoll, M.D., Sathya, G., Bambara, R.A., Hilf, R. J. Biol. Chem. (1997) [Pubmed]
  21. A retinoic acid response element that overlaps an estrogen response element mediates multihormonal sensitivity in transcriptional activation of the lactoferrin gene. Lee, M.O., Liu, Y., Zhang, X.K. Mol. Cell. Biol. (1995) [Pubmed]
  22. COUP-TF (chicken ovalbumin upstream promoter transcription factor)-interacting protein 1 (CTIP1) is a sequence-specific DNA binding protein. Avram, D., Fields, A., Senawong, T., Topark-Ngarm, A., Leid, M. Biochem. J. (2002) [Pubmed]
  23. Role of estrogen receptor ligand and estrogen response element sequence on interaction with chicken ovalbumin upstream promoter transcription factor (COUP-TF). Klinge, C.M. J. Steroid Biochem. Mol. Biol. (1999) [Pubmed]
  24. Orphan receptor COUP-TF is required for induction of retinoic acid receptor beta, growth inhibition, and apoptosis by retinoic acid in cancer cells. Lin, B., Chen, G.Q., Xiao, D., Kolluri, S.K., Cao, X., Su, H., Zhang, X.K. Mol. Cell. Biol. (2000) [Pubmed]
  25. Functional interactions between C/EBP, Sp1, and COUP-TF regulate human immunodeficiency virus type 1 gene transcription in human brain cells. Schwartz, C., Catez, P., Rohr, O., Lecestre, D., Aunis, D., Schaeffer, E. J. Virol. (2000) [Pubmed]
  26. Regulation of differential COUP-TF-coregulator interactions in adrenal cortical steroidogenesis. Shibata, H., Kurihara, I., Kobayashi, S., Yokota, K., Suda, N., Saito, I., Saruta, T. J. Steroid Biochem. Mol. Biol. (2003) [Pubmed]
  27. COUP-TF interacting protein 2 represses the initial phase of HIV-1 gene transcription in human microglial cells. Marban, C., Redel, L., Suzanne, S., Van Lint, C., Lecestre, D., Chasserot-Golaz, S., Leid, M., Aunis, D., Schaeffer, E., Rohr, O. Nucleic Acids Res. (2005) [Pubmed]
  28. Functional domains of the human orphan receptor ARP-1/COUP-TFII involved in active repression and transrepression. Achatz, G., Hölzl, B., Speckmayer, R., Hauser, C., Sandhofer, F., Paulweber, B. Mol. Cell. Biol. (1997) [Pubmed]
  29. Members of the steroid hormone receptor superfamily interact with TFIIB (S300-II). Ing, N.H., Beekman, J.M., Tsai, S.Y., Tsai, M.J., O'Malley, B.W. J. Biol. Chem. (1992) [Pubmed]
  30. Liver x receptor inhibits the synthesis and secretion of apolipoprotein A1 by human liver-derived cells. Huuskonen, J., Vishnu, M., Chau, P., Fielding, P.E., Fielding, C.J. Biochemistry (2006) [Pubmed]
  31. The nuclear receptor chicken ovalbumin upstream promoter transcription factor interacts with HIV-1 Tat and stimulates viral replication in human microglial cells. Rohr, O., Schwartz, C., Hery, C., Aunis, D., Tardieu, M., Schaeffer, E. J. Biol. Chem. (2000) [Pubmed]
  32. Differential molecular mechanism of the estrogen action that regulates lactoferrin gene in human and mouse. Teng, C.T., Liu, Y., Yang, N., Walmer, D., Panella, T. Mol. Endocrinol. (1992) [Pubmed]
WikiGenes - Universities