High impact information on DAX-1

• Ang II markedly inhibited DAX-1 protein expression in a time- and concentration-dependent manner (to 38.7 +/- 12.9% of controls at 3 nm after 6 h, p < 0.01), an effect that required de novo protein synthesis and ERK2/1 activation [1].
• These results demonstrate that the balance between repressor and inducer function of DAX-1 and SF-1 are of critical importance in the regulation of adrenal aldosterone biosynthesis [1].
• Neither Ang II nor forskolin affected DAX-1 protein and mRNA stability [1].
• Repression of DAX-1 and induction of SF-1 expression. Two mechanisms contributing to the activation of aldosterone biosynthesis in adrenal glomerulosa cells [1].
• The expression of negative regulators of CYP17 gene expression: DAX-1, COUP-TF and N-CoR was investigated in bovine adrenocortical cells in primary culture [2].

Associations of DAX-1 with chemical compounds

• The aldosterone response to Ang II was markedly reduced (to 59 +/- 4% of controls, p < 0.01) in transiently transfected cells overexpressing DAX-1 [1].

Other interactions of DAX-1

• It was found that DAX-1 and COUP-TF mRNA levels were unaffected by treatment with ACTH or forskolin [2].

References