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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Ntf-2  -  Nuclear transport factor-2

Drosophila melanogaster

Synonyms: BcDNA:GM08921, CG1740, DNTF-2, Dmel\CG1740, Dntf-2, ...
 
 
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High impact information on Ntf-2

  • We also found that DNTF-2 interacts directly with Mbo/DNup88, which does not contain phenylalanine-glycine-rich repeats, but has been shown to function in the import of Rel proteins [1].
  • The Drosophila homolog, DNTF-2, is an essential component of the nuclear import machinery, since ntf mutants are lethal [1].
  • Comparative expression analysis shows that Dntf-2r is male specific whereas the parental gene, Dntf-2, is widely expressed in D. melanogaster [2].
  • The severe eye phenotype caused by reduction of NTF2 is suppressed by loss of function mutations in chic and gain of function mutations in Sd (RanGAP) [3].
 

Analytical, diagnostic and therapeutic context of Ntf-2

References

  1. The Drosophila homolog of NTF-2, the nuclear transport factor-2, is essential for immune response. Bhattacharya, A., Steward, R. EMBO Rep. (2002) [Pubmed]
  2. Dntf-2r, a young Drosophila retroposed gene with specific male expression under positive Darwinian selection. Betrán, E., Long, M. Genetics (2003) [Pubmed]
  3. Crosstalk between the actin cytoskeleton and Ran-mediated nuclear transport. Minakhina, S., Myers, R., Druzhinina, M., Steward, R. BMC Cell Biol. (2005) [Pubmed]
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