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Gene Review

mbo  -  members only

Drosophila melanogaster

Synonyms: 1465/07, 1465/7, 88 kDa nuclear pore complex protein, CG6819, DNup88, ...
 
 
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High impact information on mbo

 

Biological context of mbo

  • Nuclear import of an nuclear localization signal-enhanced green fluorescent protein (NLS-EGFP) reporter is not affected in DNup88 (members only; mbo) mutants, whereas the level of CRM1-dependent EGFP-nuclear export signal (EGFP-NES) export is increased [2].
  • Our results demonstrate that distinct nuclear import events require different nucleoporins in vivo and suggest a regulatory role for mbo in signal transduction [1].
 

Anatomical context of mbo

 

Other interactions of mbo

  • The Drosophila nucleoporin Nup88 is selectively required for nuclear accumulation of Rel proteins and full activation of the innate immune response [2].

References

  1. members only encodes a Drosophila nucleoporin required for rel protein import and immune response activation. Uv, A.E., Roth, P., Xylourgidis, N., Wickberg, A., Cantera, R., Samakovlis, C. Genes Dev. (2000) [Pubmed]
  2. The Drosophila nucleoporin DNup88 localizes DNup214 and CRM1 on the nuclear envelope and attenuates NES-mediated nuclear export. Roth, P., Xylourgidis, N., Sabri, N., Uv, A., Fornerod, M., Samakovlis, C. J. Cell Biol. (2003) [Pubmed]
  3. The nucleoporin Nup214 sequesters CRM1 at the nuclear rim and modulates NF{kappa}B activation in Drosophila. Xylourgidis, N., Roth, P., Sabri, N., Tsarouhas, V., Samakovlis, C. J. Cell. Sci. (2006) [Pubmed]
 
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