The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

mbo  -  members only

Drosophila melanogaster

Synonyms: 1465/07, 1465/7, 88 kDa nuclear pore complex protein, CG6819, DNup88, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on mbo


Biological context of mbo

  • Nuclear import of an nuclear localization signal-enhanced green fluorescent protein (NLS-EGFP) reporter is not affected in DNup88 (members only; mbo) mutants, whereas the level of CRM1-dependent EGFP-nuclear export signal (EGFP-NES) export is increased [2].
  • Our results demonstrate that distinct nuclear import events require different nucleoporins in vivo and suggest a regulatory role for mbo in signal transduction [1].

Anatomical context of mbo


Other interactions of mbo

  • The Drosophila nucleoporin Nup88 is selectively required for nuclear accumulation of Rel proteins and full activation of the innate immune response [2].


  1. members only encodes a Drosophila nucleoporin required for rel protein import and immune response activation. Uv, A.E., Roth, P., Xylourgidis, N., Wickberg, A., Cantera, R., Samakovlis, C. Genes Dev. (2000) [Pubmed]
  2. The Drosophila nucleoporin DNup88 localizes DNup214 and CRM1 on the nuclear envelope and attenuates NES-mediated nuclear export. Roth, P., Xylourgidis, N., Sabri, N., Uv, A., Fornerod, M., Samakovlis, C. J. Cell Biol. (2003) [Pubmed]
  3. The nucleoporin Nup214 sequesters CRM1 at the nuclear rim and modulates NF{kappa}B activation in Drosophila. Xylourgidis, N., Roth, P., Sabri, N., Tsarouhas, V., Samakovlis, C. J. Cell. Sci. (2006) [Pubmed]
WikiGenes - Universities