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Gene Review

cpb  -  capping protein beta

Drosophila melanogaster

Synonyms: ANCP-BETA, CAPB_DROME, CG17158, CP, CP-beta, ...
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High impact information on cpb

  • To investigate the function of profilin in the context of a differentiating cell, we have studied an instructive genetic interaction between mutations in profilin (chickadee) and capping protein (cpb) [1].
  • When its function is reduced in the Drosophila bristle, F-actin levels increase and the actin cytoskeleton becomes disorganized, causing abnormal bristle morphology. chickadee mutations suppress the abnormal bristle phenotype and associated abnormalities of the actin cytoskeleton seen in cpb mutants [1].

Biological context of cpb

  • Furthermore, overexpression of profilin in the bristle mimics many features of the cpb loss-of-function phenotype [1].


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