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Gene Review

chic  -  chickadee

Drosophila melanogaster

Synonyms: CG9553, Chi, Chic, D88, Dmel\CG9553, ...
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Psychiatry related information on chic


High impact information on chic


Biological context of chic


Anatomical context of chic


Associations of chic with chemical compounds

  • At position 362 (invariant) only the conservative change from tyrosine to phenylalanine had no effect; other changes at this position affected conformation, ATP and profilin binding [11].

Physical interactions of chic

  • Here, we show that Ena can bind directly to the Drosophila homolog of profilin, chickadee [7].

Other interactions of chic


  1. The Drosophila fragile X mental retardation protein controls actin dynamics by directly regulating profilin in the brain. Reeve, S.P., Bassetto, L., Genova, G.K., Kleyner, Y., Leyssen, M., Jackson, F.R., Hassan, B.A. Curr. Biol. (2005) [Pubmed]
  2. Ciboulot regulates actin assembly during Drosophila brain metamorphosis. Boquet, I., Boujemaa, R., Carlier, M.F., Préat, T. Cell (2000) [Pubmed]
  3. chickadee encodes a profilin required for intercellular cytoplasm transport during Drosophila oogenesis. Cooley, L., Verheyen, E., Ayers, K. Cell (1992) [Pubmed]
  4. Cooperative interactions between the central spindle and the contractile ring during Drosophila cytokinesis. Giansanti, M.G., Bonaccorsi, S., Williams, B., Williams, E.V., Santolamazza, C., Goldberg, M.L., Gatti, M. Genes Dev. (1998) [Pubmed]
  5. Spatial control of the actin cytoskeleton in Drosophila epithelial cells. Baum, B., Perrimon, N. Nat. Cell Biol. (2001) [Pubmed]
  6. Profilin and the Abl tyrosine kinase are required for motor axon outgrowth in the Drosophila embryo. Wills, Z., Marr, L., Zinn, K., Goodman, C.S., Van Vactor, D. Neuron (1999) [Pubmed]
  7. Identification of profilin and src homology 3 domains as binding partners for Drosophila enabled. Ahern-Djamali, S.M., Bachmann, C., Hua, P., Reddy, S.K., Kastenmeier, A.S., Walter, U., Hoffmann, F.M. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  8. Identification of cytoskeletal regulatory proteins required for efficient phagocytosis in Drosophila. Pearson, A.M., Baksa, K., Rämet, M., Protas, M., McKee, M., Brown, D., Ezekowitz, R.A. Microbes Infect. (2003) [Pubmed]
  9. Profilin mutations disrupt multiple actin-dependent processes during Drosophila development. Verheyen, E.M., Cooley, L. Development (1994) [Pubmed]
  10. Profilin is required for posterior patterning of the Drosophila oocyte. Manseau, L., Calley, J., Phan, H. Development (1996) [Pubmed]
  11. The binding of mutant actins to profilin, ATP and DNase I. Drummond, D.R., Hennessey, E.S., Sparrow, J.C. Eur. J. Biochem. (1992) [Pubmed]
  12. A balance of capping protein and profilin functions is required to regulate actin polymerization in Drosophila bristle. Hopmann, R., Miller, K.G. Mol. Biol. Cell (2003) [Pubmed]
  13. Distinct pathways control recruitment and maintenance of myosin II at the cleavage furrow during cytokinesis. Dean, S.O., Rogers, S.L., Stuurman, N., Vale, R.D., Spudich, J.A. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
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