Disease relevance of CAPZB

• There was no evidence for linkage to CAPB in the brain cancer-prostate cancer subset [1].
• We also examined the 1p36 (CAPB) region in 13 PRCA families with at least one case of brain cancer [1].
• 7 of the 10 subjects developed dermatitis from 1 or more CAPB-containing products at some point during the study [2].
• Patch testing with commercially-available CAPB has yielded occasional reactions indicative of allergic contact dermatitis [2].
• Thus, the study confirmed that CAPB-sensitive individuals can use a CAPB-based rinse-off product without the risk of experiencing an allergic reaction to CAPB [3].

High impact information on CAPZB

• Linkage analyses at the chromosome 1 loci 1q24-25 (HPC1), 1q42.2-43 (PCAP), and 1p36 (CAPB) in families with hereditary prostate cancer [1].
• The human alpha 2 gene (CAPZA2) has been mapped to chromosome 7 position q31.2-q31.3 and the beta gene (CAPZB) to chromosome 1 region p36.1 [4].
• Previously, the finding of the coaggregation of malignancies of the central nervous system within PC families helped to link a prostate-brain cancer susceptibility gene (CAPB) to chromosome 1p36 [5].
• Those proteins were identified to be calmodulin, protein kinase C substrate, thymosin beta-4 and F-actin capping protein beta-subunit by peptide mass fingerprinting (PMF) with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) [6].
• Static and dynamic light scattering experiments show that the mixed micelles of sodium dodecyl sulfate (SDS) and cocoamidopropyl betaine (CAPB) undergo a sphere-to-rod transition at unexpectedly low total surfactant concentrations, about 10 mM [7].

Chemical compound and disease context of CAPZB

• A significantly higher frequency of aphthous ulcers was demonstrated when the patients brushed with an SLS- than with a CAPB-containing or a detergent-free placebo paste [8].

Biological context of CAPZB

• This fragment also contains several important virulence determinants, including the capb locus, and one of the five constitutive mutants had concomitantly lost the ability to synthesise a type-b capsule [9].
• This research provided preliminary data for CAPB as a candidate in harmful algal blooms mitigation and pointed out unresolved problems for its practical application in the meantime [10].
• The biodegradation test indicated that the half-life of CAPB in seawater was shorter than one day and 90% was biodegraded after five days under the initial concentration of 100 mg/L at 25 degrees C. Further cell lysis experiments revealed the selective lysis effect of CAPB on different HAB organisms [10].

Anatomical context of CAPZB

• SLS in toothpastes significantly increased the incidence of desquamation of the oral mucosa compared with toothpastes containing the detergent CAPB [11].

Associations of CAPZB with chemical compounds

• Parallel experiments with mixed solutions of CAPB and sodium laureth sulfate (sodium dodecyl-trioxyethylene sulfate, SDP3S) showed that the sphere-to-rod transition in SDP3S/CAPB mixtures occurs at higher surfactant concentrations, above 40 mM [7].
• Taken together, these results suggest that DMAPA is unlikely to be an important contact allergen in CAPB of appropriate quality [12].
• 4 of the 7 patients were tested to purified CAPB and cocamidopropylamine, with 2 reacting to the purified betaine on allergy patch testing and 3 reacting to cocamidopropylamine 0.1% [12].
• Later, they were patch tested to 2 different purity grades of CAPB and 3 possible manufacturing contaminants (dimethylaminopropylamine, amidoamine, and sodium monochloroacetate) [2].
• Formaldehyde allergy was overrepresented in CAPB-allergic patients in this series of patients [13].

Other interactions of CAPZB

• The autoantibodies identified in more than 20% of samples included those against annexin II, F-actin capping protein beta subunit and calreticulin [14].

Analytical, diagnostic and therapeutic context of CAPZB

• The procedure was successfully employed for the assessment of CAPB and AE biodegradation in a hydroponic plant growth system used as a graywater bioreactor [15].
• 7 patients allergic to cocamidopropyl betaine (CAPB) were detected by positive patch test reactions to Tegobetaine L7TM [12].
• This double-blind cross-over study describes the oral mucosal effects of SLS-containing toothpastes and pastes containing a zwitterionic detergent, cocoamidopropyl-betaine (CAPB) in an experimental model in 28 healthy females [11].
• Less toxic detergents, e.g. CAPB, are desirable in oral hygiene products [11].

References