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Gene Review:

copS - copy 2

Streptococcus pyogenes

Cegłowski, P. et al., Dmowski, M. et al.

Dmowski, Sitkiewicz, Ceglowski,

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Disease relevance of copS

Gene organization of the Streptococcus pyogenes plasmid pDB101: sequence analysis of the orf eta-copS region [1].

High impact information on copS

The ParB-like product of the omega gene binds to three regions containing repeated WATCACW heptamers, localized in the copS (regulation of plasmid copy number), delta, and omega promoter regions [2].
The copS- and orf1-encoded proteins share homology to plasmid copy number control systems and Gram+ cocci surface proteins, respectively [1].
The gene order in pDB101 is repS-orf alpha-orf beta-orf gamma-orf delta-orf epsilon-orf zeta-erm2-erm1-orf zeta-orf epsilon-orf delta-orf gamma-orf beta-orf alpha-orf eta-orf theta-orf1-copS [1].

References

Gene organization of the Streptococcus pyogenes plasmid pDB101: sequence analysis of the orf eta-copS region. Cegłowski, P., Alonso, J.C. Gene (1994) [Pubmed]
Characterization of a novel partition system encoded by the delta and omega genes from the streptococcal plasmid pSM19035. Dmowski, M., Sitkiewicz, I., Ceglowski, P. J. Bacteriol. (2006) [Pubmed]

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